陈 晶 胡福军 叶智敏

    浙江省肿瘤医院放疗科，浙江杭州310022

    32例儿童及青少年鼻咽癌预后影响因素的临床分析

    陈晶胡福军▲叶智敏

    浙江省肿瘤医院放疗科，浙江杭州310022

    目的探讨影响儿童及青少年鼻咽癌预后的因素。方法回顾性分析我院32例经病理组织学确诊，年龄11～18岁鼻咽癌患者的病历资料，患者均采用调强放疗或放疗加化疗的综合治疗方案。用SPSS17.0统计软件进行统计分析。结果单因素分析：N分期(P=0.043)、化疗方式(P=0.003)与预后有关，而性别(P=0.375)、年龄(P= 0.096)、临床分期(P=0.136)、T分期(P=0.127)均与预后无关。多因素分析，仅N分期(P=0.031)影响预后。全部治疗结束后，临床获益率为96.9%，客观反应率87.5%，局部控制率为96.9%。结论患者预后受N分期、化疗方式影响，诱导化疗序贯调强放疗联合同步化疗的综合治疗方案安全，不良反应轻，建议N2及N3患者进行放化疗为主的综合治疗。

    鼻咽癌；儿童；放射治疗；综合治疗；预后

    [Abstract]Objectives To analyze the factors affecting prognosis of pediatric and juvenile nasopharyngeal carcinoma nasopharyngeal carcinomas.Methods The thirty-two nasopharyngeal carcinoma patients formally diagnosed by histopathology and aged between 11 and 18 years old were retrospectively analyzed.All patients received intensity-modulated radiation therapy or comprehensive treatments including radiotherapy plus chemotherapy.The SPSS 17.0 software was used for statistical analysis.Results The univariate analysis revealed that N stage(P=0.043)，chemotherapy mode(P=0.003)were related to the prognosis and sex(P=0.375) ......