2型糖尿病患者干眼与糖尿病视网膜病变的相关性研究(1)
[摘要] 目的 探讨2型糖尿病患者干眼的患病率及其与糖尿病视网膜病变的相关性。 方法 对363例住院2型糖尿病患者通过询问和病历回顾获得所有患者的临床资料，包括性别、年龄、病程、糖基化血红蛋白和其他疾病史，同时进行干眼的相关检查和对糖尿病视网膜病变进行分级。 结果 363例2型糖尿病患者中干眼97例，干眼总患病率为26.7%。2型糖尿病患者干眼的患病率和性别无关，与病程相关。无糖尿病视网膜病变(no diabetic retinopathy，NDR)组、非增生性糖尿病视网膜病变(non-proliferative diabetic retinopathy，NPDR)组及增生性糖尿病视网膜病变(proliferative diabetic retinopathy，PDR)组的干眼患病率分别为15.6%、28.7%及46.7%，三组间两两比较差异均有统计学意义(P<0.05)。HbA1c≤7%组干眼的患病率为20.5%，HbA1c >7%组干眼的患病率为34.8%，两组比较差异有统计学意义(P<0.05)。 结论 2型糖尿病患者干眼的患病率和糖尿病视网膜病变的严重程度、HbA1c相关，PDR及高HbA1c患者更易发生干眼。
[关键词] 干眼；糖尿病视网膜病变；糖基化血红蛋白；2型糖尿病
[中图分类号] R587.2；R774.1 [文献标识码] B [文章编号] 1673-9701(2016)35-0068-03
Study on the correlation between dry eye and diabetic retinopathy in the patients with type 2 diabetes
ZHUANG Guobin WU Xiaomin ZHU Meihong WANG Xiuchun ZHENG Tongmei
Department of Ophthalmology， Quanzhou First Hospital， Fujian Medical University， Quanzhou 362000， China
[Abstract] Objective To study the correlation between the prevalence of dry eye and diabetic retinopathy in patients with type 2 diabetes mellitus. Methods The clinical data of 363 inpatients with type 2 diabetes mellitus were collected by questionnaires and medical records， including gender， age， duration， glycosylated hemoglobin and other diseases. At the same time， dry eye-related examination and classification of diabetic retinopathy were carried out. Results Among the 363 patients with type 2 diabetes mellitus， 97 patients were with dry eyes and the total prevalence rate of dry eye was 26.7%. The prevalence rate of dry eye in the patients with type 2 diabetes mellitus was not associated with gender and was associated with disease duration. The prevalence of dry eye in no diabetic retinopathy(NDR) group， non-proliferative diabetic retinopathy(NPDR) group and proliferative diabetic retinopathy(PDR) group was 15.6%， 28.7% and 46.7% respectively. Any of two groups among the three groups were compared， and the differences were statistically significant(P<0.05). The prevalence rate of dry eye was 20.5% in HbA1c≤7% group and 34.8% in HbA1c> 7% group. There was statistical significance between the two groups(P<0.05). Conclusion The prevalence rate of dry eye in the patients with type 2 diabetes mellitus and the severity of diabetic retinopathy are related to HbA1c. PDR and higher HbA1c are more likely to induce dry eye.
[Key words] Dry eye； Diabetic retinopathy； Glycosylated hemoglobin； Type 2 diabetes mellitus
糖尿病是一種常见的全身疾病，其特征是慢性高血糖引起全身并发症。糖尿病可伴随很多眼部并发症，包括白内障、青光眼、视网膜病变、点状角膜病变和复发性角膜上皮糜烂[1，2]。干眼是成人常见的眼部疾病。糖尿病患者由于代谢异常或泪液分泌异常可有干眼的表现。研究表明糖尿病患者泪液蛋白组成与正常人不同[3，4]。既往有研究探讨干眼、糖尿病和糖尿病视网膜病变的关系[5-8]，然而诊断干眼的方法和标准不同，导致干眼的患病率不同，并且对干眼和糖尿病视网膜病变与糖尿病控制的相关性并不清楚。本研究目的是探讨2型糖尿病患者干眼和糖尿病视网膜病变与糖尿病控制的相关性。 (庄国斌 吴晓民 朱梅红 王秀春 郑通美)
[关键词] 干眼；糖尿病视网膜病变；糖基化血红蛋白；2型糖尿病
[中图分类号] R587.2；R774.1 [文献标识码] B [文章编号] 1673-9701(2016)35-0068-03
Study on the correlation between dry eye and diabetic retinopathy in the patients with type 2 diabetes
ZHUANG Guobin WU Xiaomin ZHU Meihong WANG Xiuchun ZHENG Tongmei
Department of Ophthalmology， Quanzhou First Hospital， Fujian Medical University， Quanzhou 362000， China
[Abstract] Objective To study the correlation between the prevalence of dry eye and diabetic retinopathy in patients with type 2 diabetes mellitus. Methods The clinical data of 363 inpatients with type 2 diabetes mellitus were collected by questionnaires and medical records， including gender， age， duration， glycosylated hemoglobin and other diseases. At the same time， dry eye-related examination and classification of diabetic retinopathy were carried out. Results Among the 363 patients with type 2 diabetes mellitus， 97 patients were with dry eyes and the total prevalence rate of dry eye was 26.7%. The prevalence rate of dry eye in the patients with type 2 diabetes mellitus was not associated with gender and was associated with disease duration. The prevalence of dry eye in no diabetic retinopathy(NDR) group， non-proliferative diabetic retinopathy(NPDR) group and proliferative diabetic retinopathy(PDR) group was 15.6%， 28.7% and 46.7% respectively. Any of two groups among the three groups were compared， and the differences were statistically significant(P<0.05). The prevalence rate of dry eye was 20.5% in HbA1c≤7% group and 34.8% in HbA1c> 7% group. There was statistical significance between the two groups(P<0.05). Conclusion The prevalence rate of dry eye in the patients with type 2 diabetes mellitus and the severity of diabetic retinopathy are related to HbA1c. PDR and higher HbA1c are more likely to induce dry eye.
[Key words] Dry eye； Diabetic retinopathy； Glycosylated hemoglobin； Type 2 diabetes mellitus
糖尿病是一種常见的全身疾病，其特征是慢性高血糖引起全身并发症。糖尿病可伴随很多眼部并发症，包括白内障、青光眼、视网膜病变、点状角膜病变和复发性角膜上皮糜烂[1，2]。干眼是成人常见的眼部疾病。糖尿病患者由于代谢异常或泪液分泌异常可有干眼的表现。研究表明糖尿病患者泪液蛋白组成与正常人不同[3，4]。既往有研究探讨干眼、糖尿病和糖尿病视网膜病变的关系[5-8]，然而诊断干眼的方法和标准不同，导致干眼的患病率不同，并且对干眼和糖尿病视网膜病变与糖尿病控制的相关性并不清楚。本研究目的是探讨2型糖尿病患者干眼和糖尿病视网膜病变与糖尿病控制的相关性。 (庄国斌 吴晓民 朱梅红 王秀春 郑通美)