血清NO水平与扁桃体切除术治疗银屑病疗效的关系(1)
[摘要] 目的 研究血清一氧化氮(NO)水平与扁桃体切除术治疗银屑病疗效的关系。 方法 采用硝酸银还原法检测30例扁桃体切除术治疗银屑病患者和20例扁桃体切除术治疗慢性扁桃体炎患者的外周血一氧化氮(NO)水平。结果 30例采用扁桃体切除术治疗银屑病患者的外周血的NO平均水平[(41.60±1.95)mmol/L]明显高于20例采用扁桃体切除术治疗慢性扁桃体炎患者的外周血NO水平[(17.50±1.26)mmol/L]，差异有高度统计学意义(P<0.01)；实验组中血清NO平均水平痊愈组[(50.88±2.64)mmol/L]明显高于好转组[(37.50±2.45)mmol/L]，好转组明显高于无效组[(23.00±1.58)mmol/L]，差异有高度统计学意义(P<0.01)。 结论 血清NO水平与扁桃体切除术治疗银屑病的疗效呈相关关系。血清NO水平可成为判断能否采用扁桃体切除术治疗银屑病有价值的指标。
[关键词] 扁桃体切除术；银屑病；血清；一氧化氮
[中图分类号] R758.63 [文献标识码] A [文章编号] 1673-9701(2017)02-0005-03
Correlation between serum nitric oxide(NO) level and curative effect of tonsillectomy in the treatment of psoriasis
WANG Huihe1 LIU Guifeng2 XU Jianhua1 XU Jingsheng1
1.Department of Otolaryngology Head and Neck Surgery，Chengyang District People's Hospital of Qingdao in Shandong Province，Qingdao 266000，China；2.Department of Health Check Center，Chengyang District People's Hospital of Qingdaoin in Shandong Province，Qingdao 266000，China
[Abstract] Objective To study the relation between serum nitric oxide(NO) level and curative effect of tonsillectomy in the treatment of psoriasis. Methods Silver nitrate reduction method was used to detect the serum nitric oxide(NO)level of peripheral blood in treatment of 30 cases of psoriasis patients and 20 cases of chronic tonsillitis patients with tonsillectomy. Results Average serum nitric oxide(NO) level in experimental group[(41.60±1.95) mmol/L] was higher than that of control group[(17.50±1.26) mmol/L] and the differences of them were statistical significant(P<0.01). In the experimental group， average serum nitric oxide(NO) level of cure group[(50.88±2.64)mmol/L] was higher than that of improvement group[(37.50±2.45)mmol/L]， and that of improvement group was higher than invalid group[(23.00±1.58)mmol/L]， and the differences of them were statistical significant(P<0.01). Conclusion The serum nitric oxide(NO) level and curative effect of tonsillectomy in the treatment of psoriasis have positive correlation. Serum nitric oxide(NO) level will probably become a valuable target for judging tonsillectomy in the treatment of psoriasis.
[Key words] Tonsillectomy； Psoriasis； Serum； Nitric oxide
銀屑病的病因不明，感染是银屑病的激发因素。有报告显示54% 的银屑病患者在扁桃体炎后加重，反复的链球菌性咽-扁桃体炎与银屑病的发作有关[1-3]。它与皮肤中的相同抗原作用而发病； 扁桃体切除后循环抗角蛋白抗体减低[4]。此外，银屑病与组织相容性抗原 HLA-B及抗链球菌溶血素O的水平有关。扁桃体切除术治疗银屑病的疗效确切，国内外大量文献报道扁桃体切除术治疗银屑病治愈率在57.00%～82.75%之间，仍有一部分患者经受手术之痛、承受经济负担，结果无效，为了减少这种情况发生，在手术之前可以先检测血清NO水平，达到一定浓度的患者可以考虑行手术治疗。现报道如下。
1 资料与方法, http://www.100md.com(王会河 刘桂凤 徐建华)
[关键词] 扁桃体切除术；银屑病；血清；一氧化氮
[中图分类号] R758.63 [文献标识码] A [文章编号] 1673-9701(2017)02-0005-03
Correlation between serum nitric oxide(NO) level and curative effect of tonsillectomy in the treatment of psoriasis
WANG Huihe1 LIU Guifeng2 XU Jianhua1 XU Jingsheng1
1.Department of Otolaryngology Head and Neck Surgery，Chengyang District People's Hospital of Qingdao in Shandong Province，Qingdao 266000，China；2.Department of Health Check Center，Chengyang District People's Hospital of Qingdaoin in Shandong Province，Qingdao 266000，China
[Abstract] Objective To study the relation between serum nitric oxide(NO) level and curative effect of tonsillectomy in the treatment of psoriasis. Methods Silver nitrate reduction method was used to detect the serum nitric oxide(NO)level of peripheral blood in treatment of 30 cases of psoriasis patients and 20 cases of chronic tonsillitis patients with tonsillectomy. Results Average serum nitric oxide(NO) level in experimental group[(41.60±1.95) mmol/L] was higher than that of control group[(17.50±1.26) mmol/L] and the differences of them were statistical significant(P<0.01). In the experimental group， average serum nitric oxide(NO) level of cure group[(50.88±2.64)mmol/L] was higher than that of improvement group[(37.50±2.45)mmol/L]， and that of improvement group was higher than invalid group[(23.00±1.58)mmol/L]， and the differences of them were statistical significant(P<0.01). Conclusion The serum nitric oxide(NO) level and curative effect of tonsillectomy in the treatment of psoriasis have positive correlation. Serum nitric oxide(NO) level will probably become a valuable target for judging tonsillectomy in the treatment of psoriasis.
[Key words] Tonsillectomy； Psoriasis； Serum； Nitric oxide
銀屑病的病因不明，感染是银屑病的激发因素。有报告显示54% 的银屑病患者在扁桃体炎后加重，反复的链球菌性咽-扁桃体炎与银屑病的发作有关[1-3]。它与皮肤中的相同抗原作用而发病； 扁桃体切除后循环抗角蛋白抗体减低[4]。此外，银屑病与组织相容性抗原 HLA-B及抗链球菌溶血素O的水平有关。扁桃体切除术治疗银屑病的疗效确切，国内外大量文献报道扁桃体切除术治疗银屑病治愈率在57.00%～82.75%之间，仍有一部分患者经受手术之痛、承受经济负担，结果无效，为了减少这种情况发生，在手术之前可以先检测血清NO水平，达到一定浓度的患者可以考虑行手术治疗。现报道如下。
1 资料与方法, http://www.100md.com(王会河 刘桂凤 徐建华)