氟桂利嗪抗菌药物联合手术治疗中枢神经系统感染患者继发癫痫的临床效果分析(1)
[摘要] 目的 分析氟桂利嗪抗菌藥物联合手术治疗中枢神经系统感染患者继发癫痫的临床效果。 方法 选择2013年2月～2016年9月就诊于我院神经内科的中枢神经系统感染后继发癫痫的患者86例。根据随机数字表法将患者分为观察组和对照组，各43例。对照组接受氟桂利嗪等抗菌药物控制感染，治疗8～10周。观察组在此基础上予癫痫病灶切除术、姑息手术和神经调控手术。比较两组患者的临床效果、不良反应情况以及预后的相关因素。 结果 观察组总有效率明显高于对照组[79.1%(34/43) vs 55.8%(24/43)]，差异有统计学意义(P<0.05)。观察组不良反应发生率明显低于对照组[30.2%(13/43) vs 53.5%(23/43)]，差异有统计学意义(P<0.05)。根据治疗效果，将患者分为有效组(58例)和无效组(28例)。有效组患者核磁共振成像、病理变化及乙型脑炎与无效组比较，差异均有统计学意义(P<0.05)。 结论 氟桂利嗪抗菌药物联合手术治疗中枢神经系统感染后继发癫痫患者的效果较好，不良反应少，其预后受核磁共振成像、病理变化及乙型脑炎因素影响。
[关键词] 中枢神经系统；感染；继发癫痫；氟桂利嗪；预后
[中图分类号] R741；R742.1 [文献标识码] B [文章编号] 1673-9701(2017)06-0096-04
[Abstract] Objective To evaluate the clinical effect of flunarizine antimicrobial agents combined with surgery in the treatment of secondary epilepsy in patients with nervous system infection. Methods 86 central nervous system infection patients with secondary epilepsy admitted in the Department of Neurology from February 2013 to September 2016 were enrolled. According to the random number table method， the patients were divided into observation group and control group， with 43 cases in each group. The control group received antimicrobial agents such as flunarizine to control the infection for 8-10 weeks. The observation group was given epilepsy lesion resection， palliative surgery and nerve regulation surgery on the basis of the treatment in the control group. The clinical effect， adverse reactions， and prognostic factors between the two groups were compared. Results The total effective rate of the observation group(79.1%， 34/43) was significantly higher than that of the control group(55.8%， 24/43)， and the difference was statistically significant(P<0.05). The incidence of adverse reactions in the observation group(30.2%， 13/43) was significantly lower than that in the control group (53.5%， 23/43)， and the difference was statistically significant(P<0.05). According to the treatment effect， the patients were divided into effective group(58 cases) and invalid group(28 cases). There were statistically significant differences in the magnetic resonance imaging， pathological changes and encephalitis B between the two groups(P<0.05). Conclusion Flunarizine antibiotics combined with surgery has a good effect in the treatment of secondary epilepsy after central nervous system infection in patients， with fewer adverse reactions， and the prognosis is affected by nuclear magnetic resonance imaging， pathological changes and encephalitis factors.
[Key words] Central nervous system； Infection； Secondary epilepsy； Flunarizine； Prognosis, 百拇医药(陈烁 陈敬)
[关键词] 中枢神经系统；感染；继发癫痫；氟桂利嗪；预后
[中图分类号] R741；R742.1 [文献标识码] B [文章编号] 1673-9701(2017)06-0096-04
[Abstract] Objective To evaluate the clinical effect of flunarizine antimicrobial agents combined with surgery in the treatment of secondary epilepsy in patients with nervous system infection. Methods 86 central nervous system infection patients with secondary epilepsy admitted in the Department of Neurology from February 2013 to September 2016 were enrolled. According to the random number table method， the patients were divided into observation group and control group， with 43 cases in each group. The control group received antimicrobial agents such as flunarizine to control the infection for 8-10 weeks. The observation group was given epilepsy lesion resection， palliative surgery and nerve regulation surgery on the basis of the treatment in the control group. The clinical effect， adverse reactions， and prognostic factors between the two groups were compared. Results The total effective rate of the observation group(79.1%， 34/43) was significantly higher than that of the control group(55.8%， 24/43)， and the difference was statistically significant(P<0.05). The incidence of adverse reactions in the observation group(30.2%， 13/43) was significantly lower than that in the control group (53.5%， 23/43)， and the difference was statistically significant(P<0.05). According to the treatment effect， the patients were divided into effective group(58 cases) and invalid group(28 cases). There were statistically significant differences in the magnetic resonance imaging， pathological changes and encephalitis B between the two groups(P<0.05). Conclusion Flunarizine antibiotics combined with surgery has a good effect in the treatment of secondary epilepsy after central nervous system infection in patients， with fewer adverse reactions， and the prognosis is affected by nuclear magnetic resonance imaging， pathological changes and encephalitis factors.
[Key words] Central nervous system； Infection； Secondary epilepsy； Flunarizine； Prognosis, 百拇医药(陈烁 陈敬)