盐酸氨溴索治疗慢性支气管炎急性发作的疗效观察及机制分析(1)
[摘要] 目的 探討盐酸氨溴索治疗慢性支气管炎急性发作的疗效及机制。 方法 选取2013年7月～2015年7月在我院接受治疗的86例慢性支气管炎急性发作患者为研究对象，随机分为对照组和实验组，每组43例，两组患者均给予常规抗感染、止咳、解痉平喘及对症治疗，对照组运用莫西沙星治疗，实验组在对照组的基础上运用盐酸氨溴索注射液治疗，分析两组治疗前后各项指标变化情况、临床疗效、不良反应发生率。 结果 治疗前，两组各项指标变化情况比较差异无统计学意义(P>0.05)；治疗后，观察组各项指标改善程度比对照组患者改善程度更好，组间比较具有统计学意义(P<0.05)；观察组治疗总有效率为97.67%高于对照组76.74%，组间比较具有统计学意义(P<0.05)；观察组不良反应发生率为7.00%低于对照组25.58%，组间比较具有统计学意义(P<0.05)。 结论 盐酸氨溴索治疗慢性支气管炎急性发作的疗效显著，祛痰效果好，改善了临床症状和生活质量，降低了不良反应发生率，提高了治愈率，临床上值得推广应用。
[关键词] 盐酸氨溴索；支气管炎；慢性；急性发作；药物评价
[中图分类号] R562.2+1 [文献标识码] B [文章编号] 1673-9701(2017)09-0071-04
Curative effect observation and the mechanism analysis of ambroxol hydrochloride in the treatment of acute attack of chronic bronchitis
FANG Shuzhen1 CAI Chang2
1.Department of General Internal Medicine，Yiwu Third People’s Hospital in Zhejiang Province，Yiwu 322000，China；
2.Wenzhou Medical University，Wenzhou 325000，China
[Abstract] Objective To investigate the efficacy and the mechanism of ambroxol hydrochloride in the treatment of acute attack of chronic bronchitis. Methods 86 patients with acute attack of chronic bronchitis who were treated in our hospital from July 2013 to July 2015 were selected as study subjects， and they were randomly divided into the control group and the experimental group， with 43 patients in each group. Patients of two groups were given routine anti-infection， anti-cough， antispasmodic and symptomatic treatment. The control group was given moxifloxacin， and the experimental group was given ambroxol hydrochloride injection on the basis of the control group. Changes of the indices， clinical efficacy， and incidence of adverse reactions were analyzed and compared between the two groups before and after the treatment. Results There were no statistically significant differences in the changes of the indices between the two groups before treatment(P>0.05). After the treatment， the improvement of the indices in the observation group were better than those in the control group， and the differences between the two groups were statistically significant(P<0.05)； the total effective rate was 97.67% in the observation group， which was higher than that of in the control group (76.74%). There was statistically significant difference between the two groups(P<0.05)； the incidence of adverse reactions was 7.00% in the observation group， which was lower than that in the control group(25.58%)， and the difference between two groups was statistically significant(P<0.05). Conclusion The efficacy of ambroxol hydrochloride in the treatment of acute attack of chronic bronchitis is significant， expectorant effect is good， the clinical symptoms and quality of life are improved， the incidence of adverse reactions is reduced， and the cure rate is enhanced， which is clinically worthy of popularization and application., http://www.100md.com(方淑贞 蔡畅)
[关键词] 盐酸氨溴索；支气管炎；慢性；急性发作；药物评价
[中图分类号] R562.2+1 [文献标识码] B [文章编号] 1673-9701(2017)09-0071-04
Curative effect observation and the mechanism analysis of ambroxol hydrochloride in the treatment of acute attack of chronic bronchitis
FANG Shuzhen1 CAI Chang2
1.Department of General Internal Medicine，Yiwu Third People’s Hospital in Zhejiang Province，Yiwu 322000，China；
2.Wenzhou Medical University，Wenzhou 325000，China
[Abstract] Objective To investigate the efficacy and the mechanism of ambroxol hydrochloride in the treatment of acute attack of chronic bronchitis. Methods 86 patients with acute attack of chronic bronchitis who were treated in our hospital from July 2013 to July 2015 were selected as study subjects， and they were randomly divided into the control group and the experimental group， with 43 patients in each group. Patients of two groups were given routine anti-infection， anti-cough， antispasmodic and symptomatic treatment. The control group was given moxifloxacin， and the experimental group was given ambroxol hydrochloride injection on the basis of the control group. Changes of the indices， clinical efficacy， and incidence of adverse reactions were analyzed and compared between the two groups before and after the treatment. Results There were no statistically significant differences in the changes of the indices between the two groups before treatment(P>0.05). After the treatment， the improvement of the indices in the observation group were better than those in the control group， and the differences between the two groups were statistically significant(P<0.05)； the total effective rate was 97.67% in the observation group， which was higher than that of in the control group (76.74%). There was statistically significant difference between the two groups(P<0.05)； the incidence of adverse reactions was 7.00% in the observation group， which was lower than that in the control group(25.58%)， and the difference between two groups was statistically significant(P<0.05). Conclusion The efficacy of ambroxol hydrochloride in the treatment of acute attack of chronic bronchitis is significant， expectorant effect is good， the clinical symptoms and quality of life are improved， the incidence of adverse reactions is reduced， and the cure rate is enhanced， which is clinically worthy of popularization and application., http://www.100md.com(方淑贞 蔡畅)