Raf—1、MEK—2、ERK—1在胃癌组织中的表达及其意义(4)
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[12]Tan X，Tamori Y，Egami H，et al.Analysis of invasion-metastasis mechanism in pancreatic cancer：involvement of tight junctiontransmembrane protein occludin and MEK/ERK signal transduction pathway in cancer cell dissociation[J].Oncol Rep，2004，11(5)：993-998.
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[14]Meng F，Dong B，Li H，et al.RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer[J].Cancer Biol Ther，2009，8(2)：174-179.
[15]James AM，Linda SS，William HC，et al.Roles of the Raf/MEK/ERK pathway in cell growth，malignant transformation and drug resisitance[J].Biochimicaet Biop hysica Acta，2007，1771：1263-1284.
[16]Steelman LS，Franklin RA，Abrams SL，et al.Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy[J].Leu-kemia，2011，25(7)：1080-1094., 百拇医药(姜浩 孙治国)
[9]丁桂霞，张爱华， 陈荣华.Ras/Raf/ERK 信号传导通路在肾脏疾病中作用的研究进展[J].国外医学(儿科学分册)，2000，27(5)：231-235.
[10]Ramnath N，Adjei A.Inhibitors of Raf kinase and MEK signaling[J].Update On Cancer Therapeutics，2007，2：111-118.
[11]Wang D，Boerner SA，Winkler JD，et al.Clinical experience of MEK inhibitors in cancer therapy[J]. Biochimicaet Biophysica Acta，2007，1773：1248-1255.
[12]Tan X，Tamori Y，Egami H，et al.Analysis of invasion-metastasis mechanism in pancreatic cancer：involvement of tight junctiontransmembrane protein occludin and MEK/ERK signal transduction pathway in cancer cell dissociation[J].Oncol Rep，2004，11(5)：993-998.
[13]Viala E，Pouyssegur J.Regulation of tumor cell motility by ERK mitogen-activated protein kinases[J].Ann NY Acad Sci，2004，1030：208-218.
[14]Meng F，Dong B，Li H，et al.RNAi-mediated inhibition of Raf-1 leads to decreased angiogenesis and tumor growth in gastric cancer[J].Cancer Biol Ther，2009，8(2)：174-179.
[15]James AM，Linda SS，William HC，et al.Roles of the Raf/MEK/ERK pathway in cell growth，malignant transformation and drug resisitance[J].Biochimicaet Biop hysica Acta，2007，1771：1263-1284.
[16]Steelman LS，Franklin RA，Abrams SL，et al.Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy[J].Leu-kemia，2011，25(7)：1080-1094., 百拇医药(姜浩 孙治国)