[摘要] 目的 探讨米氮平与帕罗西汀治疗抑郁症伴睡眠障碍临床治疗效果。 方法 随机选取2014年6月～2015年12月我院收治的60例抑郁症伴睡眠障碍患者，随机均分为对照组(予帕罗西汀)与观察组(予米氮平)。观察两组患者的疗效和睡眠改善程度。 结果 两组患者的临床治疗效果比较差异无统计学意义，其中观察组为83.3%，而对照组为80.0%，但是观察组患者的睡眠障碍改善程度明显优于对照组，观察组治疗8周后HAMA评分为(5.79±2.12)分，明显低于对照组的(7.34±2.09)分，且差异具有统计学意义(P<0.05)。 结论 米氮平抗抑郁，尤其是治疗抑郁症伴睡眠障碍患者疗效确切，起效快，并且患者治疗依从性高，较少出现不良反应，具有良好的治疗安全性，值得在临床应用中推广。

    [关键词] 米氮平；帕罗西汀；抑郁症；睡眠障碍

    [中图分类号] R749.4 [文献标识码] B [文章编号] 1673-9701(2017)15-0095-03

    [Abstract] Objective To investigate the clinical effect of mirtazapine and paroxetine in the treatment of depression with sleep disorders. Methods 60 depression patients with sleep disorders in our hospital from June 2014 to December 2015 were randomly selected. They were randomly divided into control group(paroxetine) and observation group(mirtazapine). The efficacy and sleep improvement degree of the two groups were observed. Results The difference in clinical effect between the two groups had no statistically significant. The clinical effect of the observation group was 83.3% ......