加味益胃汤治疗原发性干燥综合征的临床观察(1)
[摘要] 目的 分析原发性干燥综合征应用中药加味益胃汤治疗的效果。 方法 随机选择2015年3月～2016年5月在本院接受治疗的原发性干燥综合征患者60例参与研究，随机分为两组，对照组利用常规药物对患者进行治疗，观察组在对照组基础上加用中药加味益胃汤治疗，比较两组治疗临床效果。 结果 观察组治疗总有效率为93.33%，对照组为76.67%，两者比较差异有统计学意义(P<0.05)；观察组治疗后Schirmer Ⅰ试验结果高于对照组，静态唾液流量多于对照组，两组比较差异有统计学意义(P<0.05)；观察组治疗后免疫球蛋白IgG、IgM、IgA指标结果均低于对照组，两组比较差异有统计学意义(P<0.05)。 结论 加味益胃汤用于治疗原发性干燥综合征患者，能够更有效改善临床症状，改善Schirmer Ⅰ试验结果，增加静态唾液流量，改善免疫球蛋白情况。
[关键词] 原发性干燥综合征；加味益胃汤；中药；治疗；免疫球蛋白
[中图分类号] R593 [文献标识码] B [文章编号] 1673-9701(2017)16-0125-03
[Abstract] Objective To analyze the effect of traditional Chinese medicine Modified Yiwei soup on primary Sjogren's syndrome. Methods 60 patients with primary sjogren's syndrome who were treated in our hospital from March 2015 to May 2015 were randomly divided into two groups. The control group was treated with conventional drugs. The observation group was treated with Chinese medicine modified yiwei soup based on the treatment of the control group. And the clinical effect between the two groups was compared. Results The total effective rate of treatment was 93.33% in the observation group and 76.67% in the control group. The difference between the two groups was statistically significant (P<0.05). After treatment， the Schirmer Ⅰ test results and the static saliva flow in the observation group were higher than those in the control group，and the difference between the two groups was statistically significant (P<0.05). The results of immunoglobulin IgG， IgM and IgA in the observation group were lower than those in the control group， and the difference was statistically significant(P<0.05). Conclusion Modified Yiyi soup for the treatment of patients with primary sjogren's syndrome can improve clinical symptoms and Schirmer Ⅰ test results， increase static saliva flow and improve immunoglobulin.
[Key words] Primary sjogren's syndrome； Modified yiwei soup； Traditional Chinese medicine； Treatment； Immunoglobulin
原發性干燥综合征属于自身免疫性疾病，主要会侵犯机体分泌腺，唾液腺及泪腺受累多见，很容易导致患者口眼干燥，同时还会出现高球蛋白血症及多种内脏损害表现等[1]。中医研究认为原发性干燥综合征应该列入中医“燥痹”范畴，治疗原则应以养阴之法为根本。中医中药对于原发性干燥综合征的治疗还没有统一的临床方法及标准，本研究是在常规西药治疗的基础上加用加味益胃汤治疗原发性干燥综合征，并观察临床效果，现报道如下。
1 资料与方法
1.1 一般资料
60例患者均来源于我院2015年3月～2016年5月接受治疗的原发性干燥综合征患者，按照随机分配原则分为观察组和对照组两组。其中观察组30例，男17例，女13例，年龄最低31岁，最高63岁，平均(52.2±4.2)岁，病程最短2年，最长8年，平均(5.8±2.3)年。对照组30例，男16例，女14例，年龄最低32岁，最高64岁，平均(52.8±4.5)岁，病程最短3年，最长9年，平均病程(6.1±2.5)年。两组各项基本资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2 纳入与排除标准
1.2.1 纳入标准 符合干燥综合症诊断标准[2]；患者病程均在10年以下，参与本次研究前3个月没有服用过激素及免疫抑制剂；自愿参与本次研究并签署知情同意书。, http://www.100md.com(孟庆一 肖瑞崇 李东书)
[关键词] 原发性干燥综合征；加味益胃汤；中药；治疗；免疫球蛋白
[中图分类号] R593 [文献标识码] B [文章编号] 1673-9701(2017)16-0125-03
[Abstract] Objective To analyze the effect of traditional Chinese medicine Modified Yiwei soup on primary Sjogren's syndrome. Methods 60 patients with primary sjogren's syndrome who were treated in our hospital from March 2015 to May 2015 were randomly divided into two groups. The control group was treated with conventional drugs. The observation group was treated with Chinese medicine modified yiwei soup based on the treatment of the control group. And the clinical effect between the two groups was compared. Results The total effective rate of treatment was 93.33% in the observation group and 76.67% in the control group. The difference between the two groups was statistically significant (P<0.05). After treatment， the Schirmer Ⅰ test results and the static saliva flow in the observation group were higher than those in the control group，and the difference between the two groups was statistically significant (P<0.05). The results of immunoglobulin IgG， IgM and IgA in the observation group were lower than those in the control group， and the difference was statistically significant(P<0.05). Conclusion Modified Yiyi soup for the treatment of patients with primary sjogren's syndrome can improve clinical symptoms and Schirmer Ⅰ test results， increase static saliva flow and improve immunoglobulin.
[Key words] Primary sjogren's syndrome； Modified yiwei soup； Traditional Chinese medicine； Treatment； Immunoglobulin
原發性干燥综合征属于自身免疫性疾病，主要会侵犯机体分泌腺，唾液腺及泪腺受累多见，很容易导致患者口眼干燥，同时还会出现高球蛋白血症及多种内脏损害表现等[1]。中医研究认为原发性干燥综合征应该列入中医“燥痹”范畴，治疗原则应以养阴之法为根本。中医中药对于原发性干燥综合征的治疗还没有统一的临床方法及标准，本研究是在常规西药治疗的基础上加用加味益胃汤治疗原发性干燥综合征，并观察临床效果，现报道如下。
1 资料与方法
1.1 一般资料
60例患者均来源于我院2015年3月～2016年5月接受治疗的原发性干燥综合征患者，按照随机分配原则分为观察组和对照组两组。其中观察组30例，男17例，女13例，年龄最低31岁，最高63岁，平均(52.2±4.2)岁，病程最短2年，最长8年，平均(5.8±2.3)年。对照组30例，男16例，女14例，年龄最低32岁，最高64岁，平均(52.8±4.5)岁，病程最短3年，最长9年，平均病程(6.1±2.5)年。两组各项基本资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2 纳入与排除标准
1.2.1 纳入标准 符合干燥综合症诊断标准[2]；患者病程均在10年以下，参与本次研究前3个月没有服用过激素及免疫抑制剂；自愿参与本次研究并签署知情同意书。, http://www.100md.com(孟庆一 肖瑞崇 李东书)