[摘要] 甲状腺激素参与机体重要的生理功能，血管内皮细胞是甲状腺激素作用的重要靶细胞之一。甲状腺功能减退影响心血管系统功能，促进动脉粥样硬化的发生与发展。一氧化氮主要由内皮性一氧化氮合酶(eNOS)催化生成，具有使血管舒张等功能，生理含量下对血管内皮具有保护作用。甲状腺功能减退导致eNOS活性降低，血浆一氧化氮含量下降导致血管内皮损伤，成为动脉粥样硬化的危险因素，增加患心血管系统疾病风险，及时行替代治疗可降低心血管内皮功能损伤。

    [关键词] 一氧化氮；内皮性一氧化氮合酶；甲状腺功能减退；血管内皮损伤

    [中图分类号] R581.2 [文献标识码] A [文章编号] 1673-9701(2017)28-0164-05

    [Abstract] Thyroid hormone is involved in the important physiological functions of the body. Vascular endothelial cells are one of the key target cells of thyroid hormone. Hypothyroidism affects cardiovascular system function and promotes the occurrence and development of atherosclerosis. Nitric oxide is mainly catalyzed and produced by endothelial nitric oxide synthase (eNOS) ......