结核性脑膜炎采用脑脊液置换联合鞘内注射应用效果(1)
[摘要] 目的 分析结核性脑膜炎采用脑脊液置换联合鞘内注射应用效果。 方法 收集我院2016年3月～2017年3月间结核性脑膜炎患者共118例，根据随机分组原则分为常规组(n=59)和实验组(n=59)，常规组接受常规药物治疗，实验组接受脑脊液置换联合鞘内注射治疗，比较两组患者疗效。 结果 实验组患者治疗总有效率为96.61%(57/59)；常规组患者治疗总有效率为81.36%(48/59)，实验组患者治疗总有效率显著高于常规组，差异有统计学意义(P<0.05)；实验组患者症状缓解时间明显短于常规组，差异有统计学意义(P<0.05)。 结论 除了常规药物治疗外，采用脑脊液置换联合鞘内注射能够缩短患者的症状缓解时间，提升整体治疗效果，临床中值得推广使用。
[关键词] 结核性脑膜炎；脑脊液置换；鞘内注射；异烟肼
[中图分类号] R529.3 [文献标识码] B [文章编号] 1673-9701(2018)02-0066-03
[Abstract] Objective To analyze the application effect of cerebrospinal fluid replacement combined with intrathecal injection in the treatment of tuberculous meningitis. Methods A total of 118 patients with tuberculous meningitis in our hospital were collected from March 2016 to March 2017. According to the principle of randomization， the patients were divided into routine group(n=59) and experimental group(n=59). The routine group was given routine drug treatment， and the experimental group was given cerebrospinal fluid replacement combined with intrathecal injection therapy. The efficacy of two groups of patients were observed and compared. Results The total effective rate in the experimental group was 96.61%(57/59)； the total effective rate in the patients in the routine group was 81.36%(48/59). The total effective rate in the experimental group was significantly higher than that in the routine group，the difference was statistical significance between the two groups(P<0.05)； the symptom relief time in the experimental group was significantly shorter than that in the routine group， the difference was statistical significance between the two groups(P<0.05). Conclusion In addition to the conventional drug treatment， the combination of cerebrospinal fluid replacement and intrathecal injection can shorten the time for symptom relief in the patients and improve the overall therapeutic effect. It is worthy of promotion and application in clinical practice.
[Key words] Tuberculous meningitis；Cerebrospinal fluid replacement；Intrathecal infection；Isoniazide
臨床神经系统结核病中最为常见的一种疾病便是结核性脑膜炎[1-3]，该病具有后遗症多、患者治疗效果差同时病死率较高等诸多特点，属于结核杆菌所引发的脑膜非化脓性炎性疾病[4]。相关资料报道称随着我国社会的发展此类患者人数呈现出明显增多趋势[5]。该病多呈亚急性，患者多存在畏光、发热、酸痛及盗汗等情况，随着人们研究发现，采用脑脊液置换联合鞘内注射可达到较为理想的治疗效果[6]，我院对59例患者使用脑脊液置换联合鞘内注射，现报道如下。
1 资料与方法
1.1一般资料
选择2016年3月～2017年3月间于我院治疗的结核性脑膜炎患者共118例，根据随机分组原则分为常规组(n=59)和实验组(n=59)，常规组接受常规药物治疗，实验组接受脑脊液置换联合鞘内注射治疗，比较两组患者疗效。实验组中男33例，女26例，年龄20～65岁，平均(32.3±8.1)岁；常规组中男31例，女28例，年龄22～67岁，平均(33.4±7.5)岁；研究中所有患者均出现了不同程度的抽出、呕吐、意识障碍及脑膜刺激等情况，同时均通过脑部CT、症状以及病史确诊。研究中排除心肝肾等功能严重受损患者及语言障碍患者、精神病史患者。本次研究中所有患者均签署知情同意书，同时经过我院伦理会审核批准，研究相关程序满足伦理学标准，两组患者的一般资料比较差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(陈宇)
[关键词] 结核性脑膜炎；脑脊液置换；鞘内注射；异烟肼
[中图分类号] R529.3 [文献标识码] B [文章编号] 1673-9701(2018)02-0066-03
[Abstract] Objective To analyze the application effect of cerebrospinal fluid replacement combined with intrathecal injection in the treatment of tuberculous meningitis. Methods A total of 118 patients with tuberculous meningitis in our hospital were collected from March 2016 to March 2017. According to the principle of randomization， the patients were divided into routine group(n=59) and experimental group(n=59). The routine group was given routine drug treatment， and the experimental group was given cerebrospinal fluid replacement combined with intrathecal injection therapy. The efficacy of two groups of patients were observed and compared. Results The total effective rate in the experimental group was 96.61%(57/59)； the total effective rate in the patients in the routine group was 81.36%(48/59). The total effective rate in the experimental group was significantly higher than that in the routine group，the difference was statistical significance between the two groups(P<0.05)； the symptom relief time in the experimental group was significantly shorter than that in the routine group， the difference was statistical significance between the two groups(P<0.05). Conclusion In addition to the conventional drug treatment， the combination of cerebrospinal fluid replacement and intrathecal injection can shorten the time for symptom relief in the patients and improve the overall therapeutic effect. It is worthy of promotion and application in clinical practice.
[Key words] Tuberculous meningitis；Cerebrospinal fluid replacement；Intrathecal infection；Isoniazide
臨床神经系统结核病中最为常见的一种疾病便是结核性脑膜炎[1-3]，该病具有后遗症多、患者治疗效果差同时病死率较高等诸多特点，属于结核杆菌所引发的脑膜非化脓性炎性疾病[4]。相关资料报道称随着我国社会的发展此类患者人数呈现出明显增多趋势[5]。该病多呈亚急性，患者多存在畏光、发热、酸痛及盗汗等情况，随着人们研究发现，采用脑脊液置换联合鞘内注射可达到较为理想的治疗效果[6]，我院对59例患者使用脑脊液置换联合鞘内注射，现报道如下。
1 资料与方法
1.1一般资料
选择2016年3月～2017年3月间于我院治疗的结核性脑膜炎患者共118例，根据随机分组原则分为常规组(n=59)和实验组(n=59)，常规组接受常规药物治疗，实验组接受脑脊液置换联合鞘内注射治疗，比较两组患者疗效。实验组中男33例，女26例，年龄20～65岁，平均(32.3±8.1)岁；常规组中男31例，女28例，年龄22～67岁，平均(33.4±7.5)岁；研究中所有患者均出现了不同程度的抽出、呕吐、意识障碍及脑膜刺激等情况，同时均通过脑部CT、症状以及病史确诊。研究中排除心肝肾等功能严重受损患者及语言障碍患者、精神病史患者。本次研究中所有患者均签署知情同意书，同时经过我院伦理会审核批准，研究相关程序满足伦理学标准，两组患者的一般资料比较差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(陈宇)