慢性心力衰竭患者心功能分级与血清尿酸、CA125、BNP水平的相关性分析(1)
[摘要] 目的 研究血清尿酸、CA125及BNP水平在慢性心力衰竭不同心功能分级患者中的水平变化，以此作为诊断依据并制定治疗方案。 方法 选取2016年3月～2017年5月在我院接受治疗的40例慢性心力衰竭患者为研究组，并按照NYHA分级标准对其进行分级，同时选取在我院接受体检的20例健康人为对照组，对两组受试者的血清尿酸、CA125、BNP水平进行检测并分析检验结果，结合不同心功能分级的各项指标，分析相关指标与受试者心功能之间的相关性。 结果 研究组HYHA各级别患者的血清尿酸、CA125及BNP水平均高于对照组，且心功能级别越高，各项指标的水平越高，差异具有统计学意义(P<0.05)。患者的心功能等级越高，其左心房直径和左室舒张末内径越高，与此同时左室射血分数则逐渐降低，差异具有统计学意义(P<0.05)。 结论 慢性心力衰竭患者的血清尿酸、CA125及BNP这三项指标的水平变化与其心功能分级呈正相关性，可以较为准确地对患者进行病情评估，从而帮助患者制定有效的治疗方案，对其治疗和预后提供参考建议，值得推广。
[关键词] 慢性心力衰竭；CA125；BNP；血清尿酸；左心房内径；左室舒张末内径；左室射血分数
[中图分类号] R541.6 [文献标识码] A [文章编号] 1673-9701(2018)07-0024-03
[Abstract] Objective To study the changes of serum uric acid， CA125 and BNP levels in chronic heart failure patients with different cardiac function classification which is to be as a basis for diagnosis， and to develop the treatment plan. Methods 40 patients with chronic heart failure treated in our hospital from March 2016 to May 2017 were selected as the study group and were graded according to the NYHA classification criteria. At the same time， the 20 healthy patients who received physical examination in our hospital were chosen as the control group. The levels of serum uric acid， CA125 and BNP in two groups were detected and analyzed， and the correlation between indicators and cardiac function in patients was analyzed in combination with the indexes of patients with different cardiac function. Results The levels of serum uric acid， CA125 and BNP in the study group were higher than those in the control group. The higher the level of heart function， the higher the level of each index， and the difference was statistically significant(P<0.05). The higher the level of cardiac function was， the higher the left atrium diameter and the diastolic diameter of the left ventricle. Meanwhile， the left ventricular ejection fraction decreased gradually with a significant difference (P<0.05). Conclusion The levels of serum uric acid， CA125 and BNP in patients with chronic heart failure have a positive correlation with the grading of cardiac function， which can be used to evaluate patients' condition accurately and help them develop effective treatment plan. And it can also provide reference for treatment and prognosis and is worth promoting.
[Key words] Chronic heart failure； CA125； BNP； Serum uric acid； Left atrial diameter； Left ventricular end-diastolic diameter； Left ventricular ejection fraction
慢性心力衰竭的臨床症状表现无较为明显的特征，具有较大的诊断难度[1]，由于该疾病难以确诊，病情被发现时已多数进入危重期，相关报道显示[2]，近5年以来，慢性心力衰竭的致死率与恶性肿瘤几乎持平，由此可见对该疾病进行早日确诊的重要性。血清脑钠肽(Brain natriuretic peptide，BNP)是目前临床上较为常见的用来诊断心力衰竭的指标，并已被大多数相关工作人员认可[3]。近年来，随着相关研究人员的不断努力，CA125及血清尿酸在心力衰竭中的诊断作用也被提出并加以运用，相关研究人员表示[4]，血清尿酸水平与慢性心力衰竭患者的病情发展呈一种直线上升关系，该项指标含量越高患者病情越严重。为了对血清尿酸、CA125及BNP三项指标共同诊断慢性心力衰竭的效果进行验证，本研究选择2016年3月～2017年5月本院收治的40例慢性心力衰竭患者血清尿酸、CA125及BNP指标进行研究，现报道如下。, 百拇医药(杨晓燕)
[关键词] 慢性心力衰竭；CA125；BNP；血清尿酸；左心房内径；左室舒张末内径；左室射血分数
[中图分类号] R541.6 [文献标识码] A [文章编号] 1673-9701(2018)07-0024-03
[Abstract] Objective To study the changes of serum uric acid， CA125 and BNP levels in chronic heart failure patients with different cardiac function classification which is to be as a basis for diagnosis， and to develop the treatment plan. Methods 40 patients with chronic heart failure treated in our hospital from March 2016 to May 2017 were selected as the study group and were graded according to the NYHA classification criteria. At the same time， the 20 healthy patients who received physical examination in our hospital were chosen as the control group. The levels of serum uric acid， CA125 and BNP in two groups were detected and analyzed， and the correlation between indicators and cardiac function in patients was analyzed in combination with the indexes of patients with different cardiac function. Results The levels of serum uric acid， CA125 and BNP in the study group were higher than those in the control group. The higher the level of heart function， the higher the level of each index， and the difference was statistically significant(P<0.05). The higher the level of cardiac function was， the higher the left atrium diameter and the diastolic diameter of the left ventricle. Meanwhile， the left ventricular ejection fraction decreased gradually with a significant difference (P<0.05). Conclusion The levels of serum uric acid， CA125 and BNP in patients with chronic heart failure have a positive correlation with the grading of cardiac function， which can be used to evaluate patients' condition accurately and help them develop effective treatment plan. And it can also provide reference for treatment and prognosis and is worth promoting.
[Key words] Chronic heart failure； CA125； BNP； Serum uric acid； Left atrial diameter； Left ventricular end-diastolic diameter； Left ventricular ejection fraction
慢性心力衰竭的臨床症状表现无较为明显的特征，具有较大的诊断难度[1]，由于该疾病难以确诊，病情被发现时已多数进入危重期，相关报道显示[2]，近5年以来，慢性心力衰竭的致死率与恶性肿瘤几乎持平，由此可见对该疾病进行早日确诊的重要性。血清脑钠肽(Brain natriuretic peptide，BNP)是目前临床上较为常见的用来诊断心力衰竭的指标，并已被大多数相关工作人员认可[3]。近年来，随着相关研究人员的不断努力，CA125及血清尿酸在心力衰竭中的诊断作用也被提出并加以运用，相关研究人员表示[4]，血清尿酸水平与慢性心力衰竭患者的病情发展呈一种直线上升关系，该项指标含量越高患者病情越严重。为了对血清尿酸、CA125及BNP三项指标共同诊断慢性心力衰竭的效果进行验证，本研究选择2016年3月～2017年5月本院收治的40例慢性心力衰竭患者血清尿酸、CA125及BNP指标进行研究，现报道如下。, 百拇医药(杨晓燕)