苄星青霉素联合头孢三嗪治疗梅毒的疗效及安全性影响(1)
[摘要] 目的 探讨苄星青霉素联合头孢三嗪治疗梅毒的效果及安全性的影响分析。 方法 选取2016年1月～2017年1月我院皮肤性病科收治的100例梅毒患者，按照随机数字表法分为观察组和对照组，观察组采用苄星青霉素与头孢三嗪联合治疗，对照组采用阿奇霉素与头孢三嗪联合治疗。比较两组治疗效果、1年后随访RPR以及不良反应发生情况。 结果 观察组治愈率、1年后随访RPR转阴率显著高于对照组(P<0.05)，总有效率高于对照组但差异无统计学差异(P>0.05)。1年后随访，观察组RPR转阴率显著高于对照组(P<0.05)，两组不良反应发生率无统计学意义(P>0.05)，安全性均较好。 结论 苄星青霉素联合头孢三嗪对梅毒有显著的治疗效果，且不良反应发生率低，是一种有效的梅毒治疗手段。
[关键词] 苄星青霉素；头孢三嗪；梅毒；安全性
[中图分类号] R759.1 [文献标识码] B [文章编号] 1673-9701(2018)27-0067-03
[Abstract] Objective To investigate the effect and safety of benzathine penicillin combined with ceftriaxone in the treatment of syphilis. Methods 100 patients with syphilis admitted in our Department of Dermatology from January 2016 to January 2017 were enrolled and divided into the observation group and the control group according to the random number table. The observation group was treated with benzathine penicillin and ceftriaxone. The control group was treated with azithromycin and ceftriaxone. The efficacy， RPR at 1 year after follow-up， and adverse reactions between the two groups were compared. Results The cure rate of the observation group and the RPR negative rate at one year after follow-up were significantly higher than those of the control group(P<0.05). The total effective rate in the observation group was higher than that of the control group， but the difference was not statistically significant(P>0.05). At one year after follow-up， the RPR negative rate of the observation group was significantly higher than that of the control group(P<0.05). The incidence of adverse reactions was not statistically significant between two groups(P>0.05). And the safety was good. Conclusion Benzathine penicillin combined with ceftriaxone has significant therapeutic effects on syphilis and lower incidence of adverse reactions. It is an effective treatment for syphilis.
[Key words] Benzathine penicillin；Ceftriaxone；Syphilis； Safety
梅毒為强传染性疾病，在世界各地均有流行，该病近年来在我国呈现蔓延的势态，并迅速成为报道病例数最多的性病[1]。梅毒感染者皮损及分泌物，血液中含有的梅毒病原体-梅毒螺旋体作为传染源通过性接触传染给其他人[2，3]，另外，该病菌还可通过胎盘屏障由患梅毒孕妇传染给胎儿，对人类健康影响极大[4，5]。目前，临床梅毒治疗仍以抗生素为主要手段，有研究[6]表明，不同类型抗生素对梅毒的治疗效果有显著差异，探索治疗梅毒的最佳抗生素配伍，以迅速治疗梅毒症状，改善患者健康状况，具有较高的研究价值。本文探讨苄星青霉素联合头孢三嗪与阿奇霉素联合头孢三嗪两种不同治疗方式对梅毒的治疗效果与安全性差异，取得了满意的效果，现报道如下。
1 资料与方法
1.1 一般资料
选取2016年1月～2017年1月我院皮肤性病科收治的100例梅毒患者，按照随机数字表法分为观察组和对照组，观察组患者50例，男28例，女22例，年龄25～59岁，平均(38.4±4.3)岁，Ⅰ期潜伏梅毒13例、Ⅱ期梅毒37例；对照组患者50例，男31例，女19例，年龄23～62岁，平均(37.3±5.1)岁，Ⅰ期潜伏梅毒16例、Ⅱ期梅毒34例。纳入标准：①所有病例均符合《中华人民共和国卫生行业标准 WS273-2007》；②RPR、TPPA、CIA检测呈阳性；③有生殖器皮损等临床症状与不良性接触史；④患者了解治疗流程及目的，并签署知情同意书。排除标准：①对苄星青霉素、头孢三嗪过敏者；②合并严重肝肾功能不全者；③妊娠及哺乳期女性；④参与其他研究者。本次研究经院伦理委员会审核批准，两组性别、年龄、诊断分期比较无统计学差异(P>0.05)，具有可比性。, 百拇医药(费秋惠)
[关键词] 苄星青霉素；头孢三嗪；梅毒；安全性
[中图分类号] R759.1 [文献标识码] B [文章编号] 1673-9701(2018)27-0067-03
[Abstract] Objective To investigate the effect and safety of benzathine penicillin combined with ceftriaxone in the treatment of syphilis. Methods 100 patients with syphilis admitted in our Department of Dermatology from January 2016 to January 2017 were enrolled and divided into the observation group and the control group according to the random number table. The observation group was treated with benzathine penicillin and ceftriaxone. The control group was treated with azithromycin and ceftriaxone. The efficacy， RPR at 1 year after follow-up， and adverse reactions between the two groups were compared. Results The cure rate of the observation group and the RPR negative rate at one year after follow-up were significantly higher than those of the control group(P<0.05). The total effective rate in the observation group was higher than that of the control group， but the difference was not statistically significant(P>0.05). At one year after follow-up， the RPR negative rate of the observation group was significantly higher than that of the control group(P<0.05). The incidence of adverse reactions was not statistically significant between two groups(P>0.05). And the safety was good. Conclusion Benzathine penicillin combined with ceftriaxone has significant therapeutic effects on syphilis and lower incidence of adverse reactions. It is an effective treatment for syphilis.
[Key words] Benzathine penicillin；Ceftriaxone；Syphilis； Safety
梅毒為强传染性疾病，在世界各地均有流行，该病近年来在我国呈现蔓延的势态，并迅速成为报道病例数最多的性病[1]。梅毒感染者皮损及分泌物，血液中含有的梅毒病原体-梅毒螺旋体作为传染源通过性接触传染给其他人[2，3]，另外，该病菌还可通过胎盘屏障由患梅毒孕妇传染给胎儿，对人类健康影响极大[4，5]。目前，临床梅毒治疗仍以抗生素为主要手段，有研究[6]表明，不同类型抗生素对梅毒的治疗效果有显著差异，探索治疗梅毒的最佳抗生素配伍，以迅速治疗梅毒症状，改善患者健康状况，具有较高的研究价值。本文探讨苄星青霉素联合头孢三嗪与阿奇霉素联合头孢三嗪两种不同治疗方式对梅毒的治疗效果与安全性差异，取得了满意的效果，现报道如下。
1 资料与方法
1.1 一般资料
选取2016年1月～2017年1月我院皮肤性病科收治的100例梅毒患者，按照随机数字表法分为观察组和对照组，观察组患者50例，男28例，女22例，年龄25～59岁，平均(38.4±4.3)岁，Ⅰ期潜伏梅毒13例、Ⅱ期梅毒37例；对照组患者50例，男31例，女19例，年龄23～62岁，平均(37.3±5.1)岁，Ⅰ期潜伏梅毒16例、Ⅱ期梅毒34例。纳入标准：①所有病例均符合《中华人民共和国卫生行业标准 WS273-2007》；②RPR、TPPA、CIA检测呈阳性；③有生殖器皮损等临床症状与不良性接触史；④患者了解治疗流程及目的，并签署知情同意书。排除标准：①对苄星青霉素、头孢三嗪过敏者；②合并严重肝肾功能不全者；③妊娠及哺乳期女性；④参与其他研究者。本次研究经院伦理委员会审核批准，两组性别、年龄、诊断分期比较无统计学差异(P>0.05)，具有可比性。, 百拇医药(费秋惠)