人乳头瘤病毒、超薄液基细胞学检测与宫颈病变的相关性研究(1)
[摘要] 目的 研究宫颈人乳头瘤病毒(HPV-DNA)感染现状及联合超薄液基细胞学(TCT)检测在宫颈病变筛查中的应用价值。 方法 选取2014年10月～2015年12月期间在我院接受宫颈癌筛查的患者2239例，行人乳头瘤病毒(HPV-DNA)检测，对HPV阳性者行超薄液基细胞学检测(TCT)，对HPV、TCT均阳性者行阴道镜下病理活检，并以病理结果为诊断宫颈病变的金标准。 结果 2239例妇女HPV检测阳性率为9.74%(218/2239)，其中高危型HPV占8.98%(201/2239)，低危型占0.76%(17/2239)。对HPV阳性患者行宫颈超薄液基细胞学(TCT)检测，HPV阳性者TCT检测阳性率为40.37%(88/218)。对HPV、TCT均阳性的患者行阴道镜下定位宫颈活组织检查，阳性率为72.72%(64/88)。 结论 不同年龄段HPV感染阳性率不同，HPV检测在宫颈病变筛查中的敏感性高，HPV联合TCT筛查明显提高了宫颈病变的阳性率，对降低宫颈癌的发生具有重要意义。
[关键词] 人乳头瘤病毒；超薄液基细胞学检测；宫颈病变；阴道镜检查
[中图分类号] R737.33 [文献标识码] B [文章编号] 1673-9701(2018)30-0054-03
[Abstract] Objective To study the current status of cervical human papillomavirus(HPV-DNA) infection and the application value of combined ultra-thin liquid-based cytology(TCT)detection in cervical lesion screening. Methods A total of 2239 patients who were screened for cervical cancer in our hospital from October 2014 to December 2015 were enrolled in the study. Papillomavirus(HPV-DNA)detection was performed. Ultrathin liquid-based cytology(TCT)was detected for HPV-positive individuals. Colposcopy biopsy was performed on both HPV and TCT positive patients， and pathological results were used as the gold standard for diagnosing cervical lesions. Results The positive rate of HPV detection in 2239 women was 9.74% (218/2239)， of which high-risk HPV accounted for 8.98% (201/2239)， and low-risk type accounted for 0.76% (17/2239). Ultrathin liquid-based cytology (TCT) was detected for HPV-positive individuals. The positive rate of TCT in HPV-positive patients was 40.37% (88/218). Patients with positive HPV and TCT were examined by colposcopy for cervical biopsy. The positive rate was 72.72%(64/88). Conclusion The positive rate of HPV infection in different age groups is different. The sensitivity of HPV detection in cervical lesion screening is high. HPV combined with TCT screening significantly improves the positive rate of cervical lesions， which is of great significance for reducing the incidence of cervical cancer.
[Key words] Human papillomavirus；Ultra-thin liquid-based cytology；Cervical lesions；Colposcopy
宮颈癌是女性常见恶性肿瘤之一，位于女性恶性肿瘤的第2位[1]，而我国宫颈癌的发病率和死亡人数约占世界的1/3。宫颈癌发病趋向于年轻化，严重危害女性健康[2-3]，有研究提示70%以上有性生活的妇女感染HPV[4-5]。HPV的持续感染是导致宫颈病变的主要病因。通过筛查HPV感染，联合超薄液基细胞学(TCT)检测，及时发现宫颈病变并给予治疗，能有效降低宫颈癌的发生率。本文通过对2239例18～65岁妇女行人乳头瘤病毒(HPV-DNA)检测，HPV阳性者行超薄液基细胞学(TCT)检测，二者联合作为筛查方法，并以病理结果为诊断宫颈病变的金标准，研究妇女HPV感染现状，及与TCT联合检测在宫颈病变筛查中的应用价值。
1 资料与方法
1.1 一般资料
选取2014年 10月～2015 年 12 月期间在我院妇科门诊初次就诊接受宫颈癌筛查的患者 2239例，患者年龄18～65岁，平均37.86岁。对2239例患者首先行HPV检测，对HPV阳性者行TCT检测，二者均阳性者行阴道镜+宫颈活组织检查，并以病理组织学诊断为金标准。, 百拇医药(刘萍)
[关键词] 人乳头瘤病毒；超薄液基细胞学检测；宫颈病变；阴道镜检查
[中图分类号] R737.33 [文献标识码] B [文章编号] 1673-9701(2018)30-0054-03
[Abstract] Objective To study the current status of cervical human papillomavirus(HPV-DNA) infection and the application value of combined ultra-thin liquid-based cytology(TCT)detection in cervical lesion screening. Methods A total of 2239 patients who were screened for cervical cancer in our hospital from October 2014 to December 2015 were enrolled in the study. Papillomavirus(HPV-DNA)detection was performed. Ultrathin liquid-based cytology(TCT)was detected for HPV-positive individuals. Colposcopy biopsy was performed on both HPV and TCT positive patients， and pathological results were used as the gold standard for diagnosing cervical lesions. Results The positive rate of HPV detection in 2239 women was 9.74% (218/2239)， of which high-risk HPV accounted for 8.98% (201/2239)， and low-risk type accounted for 0.76% (17/2239). Ultrathin liquid-based cytology (TCT) was detected for HPV-positive individuals. The positive rate of TCT in HPV-positive patients was 40.37% (88/218). Patients with positive HPV and TCT were examined by colposcopy for cervical biopsy. The positive rate was 72.72%(64/88). Conclusion The positive rate of HPV infection in different age groups is different. The sensitivity of HPV detection in cervical lesion screening is high. HPV combined with TCT screening significantly improves the positive rate of cervical lesions， which is of great significance for reducing the incidence of cervical cancer.
[Key words] Human papillomavirus；Ultra-thin liquid-based cytology；Cervical lesions；Colposcopy
宮颈癌是女性常见恶性肿瘤之一，位于女性恶性肿瘤的第2位[1]，而我国宫颈癌的发病率和死亡人数约占世界的1/3。宫颈癌发病趋向于年轻化，严重危害女性健康[2-3]，有研究提示70%以上有性生活的妇女感染HPV[4-5]。HPV的持续感染是导致宫颈病变的主要病因。通过筛查HPV感染，联合超薄液基细胞学(TCT)检测，及时发现宫颈病变并给予治疗，能有效降低宫颈癌的发生率。本文通过对2239例18～65岁妇女行人乳头瘤病毒(HPV-DNA)检测，HPV阳性者行超薄液基细胞学(TCT)检测，二者联合作为筛查方法，并以病理结果为诊断宫颈病变的金标准，研究妇女HPV感染现状，及与TCT联合检测在宫颈病变筛查中的应用价值。
1 资料与方法
1.1 一般资料
选取2014年 10月～2015 年 12 月期间在我院妇科门诊初次就诊接受宫颈癌筛查的患者 2239例，患者年龄18～65岁，平均37.86岁。对2239例患者首先行HPV检测，对HPV阳性者行TCT检测，二者均阳性者行阴道镜+宫颈活组织检查，并以病理组织学诊断为金标准。, 百拇医药(刘萍)