TG、HDL-C、TC与糖尿病周围神经病变的相关性研究(1)
[摘要] 目的 探讨甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)与糖尿病周围神经病变的相关性，为糖尿病周围神经病变诊断提供临床依据。 方法 回顾性分析2017年1月～2018年1月在我院内分泌科确诊为糖尿病周围神经病变患者48例作为DPN组，将同期我院收治的24例2型糖尿病患者作为T2DM组，分析两组甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)等指标差异。通过Logistic回归方程分析上述指标与糖尿病周围神经病变的相关性。 结果 DPN组TG、TC、LDL-C、ApoB水平均显著高于T2DM组，HDL-C显著低于T2DM组，差异均具有统计学意义(P<0.05);Logistic回归方程分析得出，TG、TC、HDL-C、LDL-C、ApoB均为DPN发病的危险因素(P<0.05)。 结论 糖尿病周围神经病变患者血脂水平高于单纯糖尿病患者，TG、TC、HDL-C、LDL-C、ApoB水平与DPN发病关系密切，是导致神经微血管病变的重要因素。
[关键词] 甘油三酯(TG);高密度脂蛋白胆固醇(HDL-C);总胆固醇(TC);2型糖尿病;周围神经病变;相关性
[中图分类号] R587.2 [文献标识码] B [文章编号] 1673-9701(2018)35-0037-03
[Abstract] Objective To explore the correlation between triglyceride (TG)， high density lipoprotein cholesterol (HDL-C)， total cholesterol (TC) and diabetic peripheral neuropathy， and to provide a clinical basis for the diagnosis of diabetic peripheral neuropathy. Methods A total of 48 patients with diabetic peripheral neuropathy diagnosed in our hospital from January 2017 to January 2018 were retrospectively analyzed and enrolled into the DPN group. Another 24 patients with type 2 diabetes admitted to our hospital during the same period were included in the T2DM group. The differences of triglyceride (TG)， total cholesterol (TC)， high density lipoprotein cholesterol (HDL-C)， low density lipoprotein cholesterol (LDL-C)， and apolipoprotein B (ApoB) between the two groups were analyzed. And the correlation between these indicators and diabetic peripheral neuropathy were analyzed by logistic regression equation. Results The levels of TG， TC， LDL-C and ApoB in the DPN group were significantly higher than those in the T2DM group， and HDL-C was significantly lower in the DPN group than that in the T2DM group(P<0.05). Logistic regression equation analysis showed that TG， TC， and HDL-C， LDL-C， ApoB were risk factors for the onset of DPN(P<0.05). Conclusion The level of blood lipids in patients with diabetic peripheral neuropathy is higher than that in patients with diabetes alone. The levels of TG， TC and HDL-C， LDL-C， ApoB are closely related to the pathogenesis of DPN， which are important factors leading to neuromicrovascular disease.
[Key words] Triglyceride (TG); High density lipoprotein cholesterol (HDL-C); Total cholesterol (TC); Type 2 diabetes; Peripheral neuropathy; Correlation
糖尿病是臨床常见的慢性代谢性疾病，据报道，我国约有1.1亿糖尿病患者，患病率高达12%，严重威胁着人们身体健康[1]。糖尿病患者机体长期处于高血糖水平，可导致肝、肾、脑等多脏器病变，影响程度大，范围广，临床表现十分复杂，许多并发症类型均为患者致残、致死的重要因素，从而得到国内外医学界的广泛关注[2]。糖尿病周围神经病变(DPN)是糖尿病患者存在周围神经功能障碍，其发病机制尚未完全明了，有研究显示，DPN的发病与血糖水平并未表现一致性[3]。另外，有研究表明[4]，DPN患者特定神经纤维的施万细胞、郎飞结或轴锁皆受到损害，提示可能与脂质代谢紊乱相关。本研究通过回顾性分析DPN与DM患者血脂水平，探讨血脂与DPN发病的相关性，为DPN的临床诊断提供依据，现报道如下。, 百拇医药(万芳 曹玲玲 孙斐)
[关键词] 甘油三酯(TG);高密度脂蛋白胆固醇(HDL-C);总胆固醇(TC);2型糖尿病;周围神经病变;相关性
[中图分类号] R587.2 [文献标识码] B [文章编号] 1673-9701(2018)35-0037-03
[Abstract] Objective To explore the correlation between triglyceride (TG)， high density lipoprotein cholesterol (HDL-C)， total cholesterol (TC) and diabetic peripheral neuropathy， and to provide a clinical basis for the diagnosis of diabetic peripheral neuropathy. Methods A total of 48 patients with diabetic peripheral neuropathy diagnosed in our hospital from January 2017 to January 2018 were retrospectively analyzed and enrolled into the DPN group. Another 24 patients with type 2 diabetes admitted to our hospital during the same period were included in the T2DM group. The differences of triglyceride (TG)， total cholesterol (TC)， high density lipoprotein cholesterol (HDL-C)， low density lipoprotein cholesterol (LDL-C)， and apolipoprotein B (ApoB) between the two groups were analyzed. And the correlation between these indicators and diabetic peripheral neuropathy were analyzed by logistic regression equation. Results The levels of TG， TC， LDL-C and ApoB in the DPN group were significantly higher than those in the T2DM group， and HDL-C was significantly lower in the DPN group than that in the T2DM group(P<0.05). Logistic regression equation analysis showed that TG， TC， and HDL-C， LDL-C， ApoB were risk factors for the onset of DPN(P<0.05). Conclusion The level of blood lipids in patients with diabetic peripheral neuropathy is higher than that in patients with diabetes alone. The levels of TG， TC and HDL-C， LDL-C， ApoB are closely related to the pathogenesis of DPN， which are important factors leading to neuromicrovascular disease.
[Key words] Triglyceride (TG); High density lipoprotein cholesterol (HDL-C); Total cholesterol (TC); Type 2 diabetes; Peripheral neuropathy; Correlation
糖尿病是臨床常见的慢性代谢性疾病，据报道，我国约有1.1亿糖尿病患者，患病率高达12%，严重威胁着人们身体健康[1]。糖尿病患者机体长期处于高血糖水平，可导致肝、肾、脑等多脏器病变，影响程度大，范围广，临床表现十分复杂，许多并发症类型均为患者致残、致死的重要因素，从而得到国内外医学界的广泛关注[2]。糖尿病周围神经病变(DPN)是糖尿病患者存在周围神经功能障碍，其发病机制尚未完全明了，有研究显示，DPN的发病与血糖水平并未表现一致性[3]。另外，有研究表明[4]，DPN患者特定神经纤维的施万细胞、郎飞结或轴锁皆受到损害，提示可能与脂质代谢紊乱相关。本研究通过回顾性分析DPN与DM患者血脂水平，探讨血脂与DPN发病的相关性，为DPN的临床诊断提供依据，现报道如下。, 百拇医药(万芳 曹玲玲 孙斐)