左氧氟沙星在复治涂阳肺结核治疗方案中的效果分析(1)
[摘要] 目的 探讨左氧氟沙星在复治涂阳肺结核治疗方案中的临床效果。 方法 对2016年1月～2018年1月在我院治疗的120例复治涂阳肺结核患者随机分组，对照组患者给予常规治疗，实验组患者应用左氧氟沙星联合治疗，观察比较两组患者治疗效果、CT疗效、痰菌转阴率和不良反应发生率差异。 结果 实验组总有效率为98.33%，明显高于对照组(85.00%)，差异有统计学意义(P<0.05);实验组CT治疗总有效率为96.66%，高于对照组(78.33%)，差异有统计学意义(P<0.05);实验组痰菌转阴率为95.00%，高于对照组(63.33%)，差异有统计学意义(P<0.05)，实验组不良反应发生率为8.33%，低于对照组(11.67%)，但差异无统计学意义(P>0.05)。 结论 针对复治涂阳肺结核患者应用左氧氟沙星治疗可提高治疗效果及胸部CT疗效，疗效显著，安全性高，值得推广应用。
[关键词] 左氧氟沙星;复治涂阳肺结核;痰菌转阴;治疗方案
[中图分类号] R521 [文献标识码] B [文章編号] 1673-9701(2019)03-0041-03
[Abstract] Objective To explore the clinical effect of levofloxacin in the treatment of re-treated smear-positive pulmonary tuberculosis. Methods 120 patients with re-treated smear-positive pulmonary tuberculosis who were treated in our hospital from January 2016 to January 2018 were randomized. Patients in the control group were given routine treatment. Patients in the experimental group were treated with levofloxacin. The differences of treatment effect， CT curative effect， sputum negative rate and adverse reaction rate were compared between the two groups. Results The total effective rate of the experimental group was 98.33%， which was significantly higher than that of the control group(85.00%). The difference was statistically significant(P<0.05). The total effective rate of CT treatment in the experimental group was 96.66%， higher than that of the control group(78.33%). The difference was statistically significant(P<0.05). The sputum negative rate in the experimental group was 95.00%， higher than that in the control group(63.33%)， and the difference was statistically significant(P<0.05). The adverse reaction rate was 8.33% in the experimental group， lower than that in the control group(11.67%)， but the difference was not statistically significant(P>0.05). Conclusion The application of levofloxacin in the treatment of patients with re-treated smear-positive pulmonary tuberculosis can improve the therapeutic effect and the chest CT curative effect. The clinical effect is remarkable and the safety is high， which is worthy of popularization and application.
[Key words] Levofloxacin; Retreated smear-positive pulmonary tuberculosis; Sputum negative conversion; Treatment plan
肺结核为临床常见肺部传染性疾病，机体被结核杆菌感染引发疾病，具有发病率高、传染性高等特点，直接影响患者正常生活，结核病感染严重，多数患者在形式上得到控制，但大部分患者未治愈，导致更多感染[1-3]。复治涂阳肺结核是结核菌规律治疗2个月以上或不规律治疗>1个月，仍为痰涂片阳性[4]。复治涂阳肺结核患者用药史不同导致患者耐药性存在差异，因此，标准化治疗方案可能无效，因此复治涂阳肺结核有效治疗具有重要意义[5]。本文通过对我院收治的120例复治涂阳肺结核患者分组，讨论治疗方案，现报道如下。, 百拇医药(郭洋 刘宁 白国峰 等)
[关键词] 左氧氟沙星;复治涂阳肺结核;痰菌转阴;治疗方案
[中图分类号] R521 [文献标识码] B [文章編号] 1673-9701(2019)03-0041-03
[Abstract] Objective To explore the clinical effect of levofloxacin in the treatment of re-treated smear-positive pulmonary tuberculosis. Methods 120 patients with re-treated smear-positive pulmonary tuberculosis who were treated in our hospital from January 2016 to January 2018 were randomized. Patients in the control group were given routine treatment. Patients in the experimental group were treated with levofloxacin. The differences of treatment effect， CT curative effect， sputum negative rate and adverse reaction rate were compared between the two groups. Results The total effective rate of the experimental group was 98.33%， which was significantly higher than that of the control group(85.00%). The difference was statistically significant(P<0.05). The total effective rate of CT treatment in the experimental group was 96.66%， higher than that of the control group(78.33%). The difference was statistically significant(P<0.05). The sputum negative rate in the experimental group was 95.00%， higher than that in the control group(63.33%)， and the difference was statistically significant(P<0.05). The adverse reaction rate was 8.33% in the experimental group， lower than that in the control group(11.67%)， but the difference was not statistically significant(P>0.05). Conclusion The application of levofloxacin in the treatment of patients with re-treated smear-positive pulmonary tuberculosis can improve the therapeutic effect and the chest CT curative effect. The clinical effect is remarkable and the safety is high， which is worthy of popularization and application.
[Key words] Levofloxacin; Retreated smear-positive pulmonary tuberculosis; Sputum negative conversion; Treatment plan
肺结核为临床常见肺部传染性疾病，机体被结核杆菌感染引发疾病，具有发病率高、传染性高等特点，直接影响患者正常生活，结核病感染严重，多数患者在形式上得到控制，但大部分患者未治愈，导致更多感染[1-3]。复治涂阳肺结核是结核菌规律治疗2个月以上或不规律治疗>1个月，仍为痰涂片阳性[4]。复治涂阳肺结核患者用药史不同导致患者耐药性存在差异，因此，标准化治疗方案可能无效，因此复治涂阳肺结核有效治疗具有重要意义[5]。本文通过对我院收治的120例复治涂阳肺结核患者分组，讨论治疗方案，现报道如下。, 百拇医药(郭洋 刘宁 白国峰 等)