氯吡格雷治疗急性缺血性脑卒中的临床效果及对血浆大内皮素-1和血清脂蛋白-α的作用分析(1)
[摘要] 目的 探討对急性缺血性脑卒中患者选择氯吡格雷治疗后获得的临床效果以及对血浆大内皮素-1、血清脂蛋白-α产生的影响。 方法 选择我院2016年6月～2018年1月收治的120例急性缺血性脑卒中患者作为实验对象，采用抽签法分组后进行脑卒中治疗方式的研究。其中对照组(60例)选择常规疗法施治;观察组(60例)选择常规疗法+氯吡格雷施治。比较两组急性缺血性脑卒中患者ADL评分、NIHSS评分、VMCA、Lp-α以及big ET-1水平。 结果 观察组ADL评分、NIHSS评分、VMCA分别为(16.9±5.8)分、(11.2±3.3)分、(69.9±7.6)cm/s，对照组分别为(13.8±3.5)分、(14.9±3.2)分、(54.6±6.5)cm/s，同对照组对比，观察组ADL评分、NIHSS评分显著改善，VMCA显著升高(P<0.05);治疗前，两组患者的Lp-α水平无统计学意义(P>0.05)，治疗后两组患者Lp-α水平均显著下降(P<0.05)，且观察组明显优于对照组(P<0.05);治疗前，两组患者big ET-1水平无统计学意义(P>0.05)，治疗后两组患者big ET-1水平均显著下降(P<0.05)，且观察组明显优于对照组(P<0.05)。观察组和对照组各有1例谷丙转氨酶增高，但均未出现肝肾功能损害、脑出血等严重不良反应。 结论 采用氯吡格雷治疗急性缺血性脑卒中，患者ADL评分、NIHSS评分、VMCA、Lp-α以及big ET-1水平可以得到显著改善，病情好转。
[关键词] 氯吡格雷;急性缺血性脑卒中;血浆大内皮素-1;血清脂蛋白-α
[中图分类号] R743.3 [文献标识码] A [文章编号] 1673-9701(2019)08-0018-04
[Abstract] Objective To investigate the clinical effects of clopidogrel in the patients with acute ischemic stroke and its effects on plasma macroendothelin-1 and serum lipoprotein-α. Methods 120 patients with acute ischemic stroke who were admitted to our hospital from June 2016 to January 2018 were selected as experimental subjects; the lottery method was applied for grouping and the treatment methods of stroke were investigated; the control group(60 cases)： the conventional therapy was selected; the observation group(60 cases)： the conventional therapy+clopidogrel drug treatment was selected; finally， the ADL score， NIHSS score， VMCA， Lp-α and big ET-1 levels were compared between the two groups of patients with acute ischemic stroke. Results The ADL score， NIHSS score， and VMCA in the observation group were(16.9±5.8) points， (11.2±3.3) points， and (69.9±7.6) cm/s， respectively. The control group was (13.8±3.5) points， (14.9±3.2) points， (54.6±6.5) cm/s， respectively. Compared with the control group， the ADL score and NIHSS score in the observation group were significantly improved， and VMCA was increased significantly(P<0.05); before treatment， there was no statistically significant difference in Lp-α levels between the two groups(P>0.05). After treatment， the Lp-α levels in the two groups were significantly decreased(P<0.05)， and the observation group was significantly better than the control group(P<0.05); before treatment， the levels of big ET-1 in the two groups were not statistically significant(P>0.05). After treatment， the levels of big ET-1 in the two groups were significantly decreased(P<0.05)， and the observation group was significantly better than the control group(P<0.05). There was a case showing increase in alanine aminotransferase in the observation group and the control group. However， there were no serious adverse reactions such as liver and kidney dysfunction and cerebral hemorrhage. Conclusion Medical staff use clopidogrel as medical treatment of acute ischemic stroke. The ADL score， NIHSS score， VMCA， Lp-α and big ET-1 levels can be significantly improved and the condition is improved in the patients., http://www.100md.com(张青莲 周云芳 邹慧龙)
[关键词] 氯吡格雷;急性缺血性脑卒中;血浆大内皮素-1;血清脂蛋白-α
[中图分类号] R743.3 [文献标识码] A [文章编号] 1673-9701(2019)08-0018-04
[Abstract] Objective To investigate the clinical effects of clopidogrel in the patients with acute ischemic stroke and its effects on plasma macroendothelin-1 and serum lipoprotein-α. Methods 120 patients with acute ischemic stroke who were admitted to our hospital from June 2016 to January 2018 were selected as experimental subjects; the lottery method was applied for grouping and the treatment methods of stroke were investigated; the control group(60 cases)： the conventional therapy was selected; the observation group(60 cases)： the conventional therapy+clopidogrel drug treatment was selected; finally， the ADL score， NIHSS score， VMCA， Lp-α and big ET-1 levels were compared between the two groups of patients with acute ischemic stroke. Results The ADL score， NIHSS score， and VMCA in the observation group were(16.9±5.8) points， (11.2±3.3) points， and (69.9±7.6) cm/s， respectively. The control group was (13.8±3.5) points， (14.9±3.2) points， (54.6±6.5) cm/s， respectively. Compared with the control group， the ADL score and NIHSS score in the observation group were significantly improved， and VMCA was increased significantly(P<0.05); before treatment， there was no statistically significant difference in Lp-α levels between the two groups(P>0.05). After treatment， the Lp-α levels in the two groups were significantly decreased(P<0.05)， and the observation group was significantly better than the control group(P<0.05); before treatment， the levels of big ET-1 in the two groups were not statistically significant(P>0.05). After treatment， the levels of big ET-1 in the two groups were significantly decreased(P<0.05)， and the observation group was significantly better than the control group(P<0.05). There was a case showing increase in alanine aminotransferase in the observation group and the control group. However， there were no serious adverse reactions such as liver and kidney dysfunction and cerebral hemorrhage. Conclusion Medical staff use clopidogrel as medical treatment of acute ischemic stroke. The ADL score， NIHSS score， VMCA， Lp-α and big ET-1 levels can be significantly improved and the condition is improved in the patients., http://www.100md.com(张青莲 周云芳 邹慧龙)