口服骨化三醇、钙剂治疗小儿佝偻病的临床效果分析(1)
[摘要] 目的 探討口服骨化三醇、钙剂治疗小儿佝偻病的临床效果。 方法 选取2017年6月～2018年6月在我院儿科治疗的小儿佝偻病患儿84例，随机分为两组，对照组常规口服维生素D滴剂及醋酸钙治疗，观察组口服骨化三醇联合醋酸钙治疗，比较两组临床疗效、各项血生化指标变化、骨密度指标变化、身高及体质量变化。 结果 观察组治疗有效率为97.62%，明显高于对照组的78.57%，差异有统计学意义(P<0.05);观察组治疗后血钙、血磷、25-(OH)D3明显高于对照组，而BALP明显低于对照组，差异有统计学意义(P<0.05);观察组治疗后桡骨及尺骨盐水平、骨密度明显高于对照组，差异有统计学意义(P<0.05);观察组治疗后身高增长、体质量增长明显高于对照组，夜惊、多汗、枕秃等发生率明显低于对照组，差异有统计学意义(P<0.05)。 结论 口服骨化三醇、钙剂治疗小儿佝偻病临床效果显著，有效提升血钙水平和骨密度，促进患儿生长发育，降低临床症状的发生率，具有积极的临床意义。
[关键词] 小儿佝偻病;口服骨化三醇;醋酸钙;骨密度;血钙
[中图分类号] R723.2 [文献标识码] B [文章编号] 1673-9701(2019)10-0069-03
Clinical effect analysis of oral calcitriol and calcium in the treatment of infantile rickets
ZHU Dan LI Xuechen
Department of Pediatric Internal Medicine， Jiamusi Maternal and Child Health Hospital in Heilongjiang Province， Jiamusi 154002， China
[Abstract] Objective To investigate the clinical effect of oral calcitriol and calcium in the treatment of infantile rickets. Methods A total of 84 children with pediatric rickets treated in the department of pediatrics of our hospital from June 2017 to June 2018 were randomly divided into two groups. The control group received conventional oral vitamin D drops and calcium acetate. The observation group received oral calcitriol combined with calcium acetate. The clinical efficacy， blood biochemical changes， bone mineral density changes， height and body weight changes were compared between the two groups. Results The effective rate of the observation group was 97.62%， which was significantly higher than that of the control group(78.57%)， and the difference was statistically significant(P<0.05). The blood calcium， blood phosphorus and 25-(OH)D3 in the observation group after treatment were significantly higher those in the control group. The BALP in the observation group was significantly lower than that of the control group， and the difference was statistically significant(P<0.05). The tibia， ulnar salt level and bone mineral density were significantly higher in the observation group than those in the control group(P<0.05). The height growth and body mass growth of the observation group after treatment were significantly higher than those of the control group. The incidences of night terror， sweating， and baldness were significantly lower than those of the control group， and the difference was statistically significant(P<0.05). Conclusion Oral calcitriol and calcium are effective in treating children with rickets， which effectively improve blood calcium level and bone density， promote growth and development of children， reduce the incidence of clinical symptoms， and have positive clinical significance., 百拇医药(朱丹 李学臣)
[关键词] 小儿佝偻病;口服骨化三醇;醋酸钙;骨密度;血钙
[中图分类号] R723.2 [文献标识码] B [文章编号] 1673-9701(2019)10-0069-03
Clinical effect analysis of oral calcitriol and calcium in the treatment of infantile rickets
ZHU Dan LI Xuechen
Department of Pediatric Internal Medicine， Jiamusi Maternal and Child Health Hospital in Heilongjiang Province， Jiamusi 154002， China
[Abstract] Objective To investigate the clinical effect of oral calcitriol and calcium in the treatment of infantile rickets. Methods A total of 84 children with pediatric rickets treated in the department of pediatrics of our hospital from June 2017 to June 2018 were randomly divided into two groups. The control group received conventional oral vitamin D drops and calcium acetate. The observation group received oral calcitriol combined with calcium acetate. The clinical efficacy， blood biochemical changes， bone mineral density changes， height and body weight changes were compared between the two groups. Results The effective rate of the observation group was 97.62%， which was significantly higher than that of the control group(78.57%)， and the difference was statistically significant(P<0.05). The blood calcium， blood phosphorus and 25-(OH)D3 in the observation group after treatment were significantly higher those in the control group. The BALP in the observation group was significantly lower than that of the control group， and the difference was statistically significant(P<0.05). The tibia， ulnar salt level and bone mineral density were significantly higher in the observation group than those in the control group(P<0.05). The height growth and body mass growth of the observation group after treatment were significantly higher than those of the control group. The incidences of night terror， sweating， and baldness were significantly lower than those of the control group， and the difference was statistically significant(P<0.05). Conclusion Oral calcitriol and calcium are effective in treating children with rickets， which effectively improve blood calcium level and bone density， promote growth and development of children， reduce the incidence of clinical symptoms， and have positive clinical significance., 百拇医药(朱丹 李学臣)