五水头孢唑林钠在骨折术后感染预防中的效果(1)
[摘要] 目的 對五水头孢唑林钠骨折术后感染预防中的效果及其治疗有效性的进行探讨。 方法 选取2015年1月～2017年7月我院收治的进行骨折术后的患者80例，随机分为两组：对照组采取头孢唑林钠静脉滴注进行治疗，研究组采取五水头孢唑林钠静脉滴注进行治疗。比较两组患者的一般资料、治疗效果、炎症因子和生命质量评分(QOL)。 结果 研究组的治疗有效率(95.0%)高于对照组(57.5%)，差异有统计学意义(P<0.05)。对照组炎症因子表达水平[IL-6(173.3±22.1)pg/mL、TNF-α(43.3±1.1)pg/mL、IL-8(343.3±78.1)pg/mL]高于研究组[IL-6(131.1±14.5)pg/mL、TNF-α(21.4±0.7)pg/mL、IL-8(221.3±46.1)pg/mL，差异有统计学意义(P<0.05);对照组治疗后 QOL评分[身体状况(74.2±2.4)分、行为(68.6±2.6)分、自评生活质量(72.5±3.2)分和社会活动(70.4±3.7)分]低于研究组冶疗后[身体状况(83.3±3.8)分、行为(83.3±5.8)分、自评生活质量(83.9±6.3)分和社会活动(81.3±4.9)分]，差异有统计学意义(P<0.05)。 结论 采取五水头孢唑林钠来治疗骨折术后患者，有效改善了患者的生活质量评分，使炎症因子的表达得到有效降低，治疗效果良好，值得进一步在各大医院的临床上进行推广。
[关键词] 五水头孢唑林钠;骨折;术后感染;预防效果;治疗有效性
[中图分类号] R976;R683 [文献标识码] B [文章编号] 1673-9701(2019)17-0105-03
[Abstract] Objective To investigate the effect of cefazolin sodium pentahydrate on infection prevention after fracture and its therapeutic effectiveness. Methods 80 patients with fractures after surgery admitted in our hospital from January 2015 to July 2017 were randomly divided into two groups. The control group received intravenous infusion of cefazolin sodium. The study group received intravenous infusion of cefazolin sodium pentahydrate. The general data， treatment effects， inflammatory factors， and quality of life scores(QOL) were compared between the two groups. Results The treatment effective rate(95.0%) of the study group was better than that of the control group(57.5%)， and the difference was statistically significant(P<0.05). The expression level of inflammatory factors including IL-6(173.3±22.1)pg/mL， TNF-α(43.3±1.1)pg/mL and IL-8 (343.3±78.1)pg/mL in the control group was higher than IL-6(131.1±14.5)pg/mL， TNF-α(21.4±0.7)pg/mL， IL-8(221.3±46.1)pg/mL in the study group， and the difference was statistically significant(P<0.05). The QOL scores including physical condition(74.2±2.4)points， behavior(68.6±2.6)points， self-rated quality of life(72.5±3.2)points and social activities(70.4±3.7)points in the control group were lower than those of study group[(83.3±3.8)points， (83.3±5.8)points， (83.9±6.3)points and(81.3±4.9)points] after treatment. The difference was statistically significant(P<0.05). Conclusion The use of cefazolin sodium pentahydrate in the treatment of postoperative patients with fractures has effectively improved the patient's quality of life score， effectively reduced the expression of inflammatory factors， and the treatment effect is good. It is worth further clinical promotion in hospitals., 百拇医药(关敏婷 吴永林 李剑)
[关键词] 五水头孢唑林钠;骨折;术后感染;预防效果;治疗有效性
[中图分类号] R976;R683 [文献标识码] B [文章编号] 1673-9701(2019)17-0105-03
[Abstract] Objective To investigate the effect of cefazolin sodium pentahydrate on infection prevention after fracture and its therapeutic effectiveness. Methods 80 patients with fractures after surgery admitted in our hospital from January 2015 to July 2017 were randomly divided into two groups. The control group received intravenous infusion of cefazolin sodium. The study group received intravenous infusion of cefazolin sodium pentahydrate. The general data， treatment effects， inflammatory factors， and quality of life scores(QOL) were compared between the two groups. Results The treatment effective rate(95.0%) of the study group was better than that of the control group(57.5%)， and the difference was statistically significant(P<0.05). The expression level of inflammatory factors including IL-6(173.3±22.1)pg/mL， TNF-α(43.3±1.1)pg/mL and IL-8 (343.3±78.1)pg/mL in the control group was higher than IL-6(131.1±14.5)pg/mL， TNF-α(21.4±0.7)pg/mL， IL-8(221.3±46.1)pg/mL in the study group， and the difference was statistically significant(P<0.05). The QOL scores including physical condition(74.2±2.4)points， behavior(68.6±2.6)points， self-rated quality of life(72.5±3.2)points and social activities(70.4±3.7)points in the control group were lower than those of study group[(83.3±3.8)points， (83.3±5.8)points， (83.9±6.3)points and(81.3±4.9)points] after treatment. The difference was statistically significant(P<0.05). Conclusion The use of cefazolin sodium pentahydrate in the treatment of postoperative patients with fractures has effectively improved the patient's quality of life score， effectively reduced the expression of inflammatory factors， and the treatment effect is good. It is worth further clinical promotion in hospitals., 百拇医药(关敏婷 吴永林 李剑)