阿奇霉素对支原体肺炎患儿炎症反应、心功能及治疗效果的影响(1)
[摘要] 目的 探讨阿奇霉素对支原体肺炎患儿炎症反应、心功能及治疗效果的影响。 方法 选择2018年1月～2019年1月本院收治的小儿支原体肺炎者80例，按照随机数字法分为两组，各40例。所有患儿均行对症支持治疗，对照组使用红霉素，观察组使用阿奇霉素，两组均以连续治疗2周为1个疗程。进行为期1个月的门诊随访，比较干预后两组炎症因子相关指标及心功能相关指标变化情况，统计整体临床治疗效果。 结果 干预后，观察组hs-CRP、IL-6、TNF-α水平均低于对照组(P<0.05);观察组心功能相关指标中NY-HA分级、BNP水平低于对照组(P<0.05)，LVEF水平高于对照组(P<0.05)，观察组有效率显著高于对照组(P<0.05)。 结论 针对小儿支原体感染肺炎，使用阿奇霉素能有效降低机体炎症反应，改善心功能，提高整体临床治疗效果。
[关键词] 阿奇霉素;小儿;支原体肺炎;心功能
[中图分类号] R725.6 [文献标识码] B [文章编号] 1673-9701(2019)24-0057-03
[Abstract] Objective To investigate the effect of azithromycin on inflammatory response， cardiac function and therapeutic effect in children with mycoplasmal pneumonia. Methods 80 children with mycoplasmal pneumonia admitted to our hospital from January 2018 to January 2019 were enrolled. According to the random number method， they were divided into two groups， with 40 cases in each group. All patients underwent symptomatic supportive treatment. The control group received erythromycin， and the observation group used azithromycin. Both groups received continuous treatment for two weeks as a course of treatment. A one-month outpatient follow-up was performed. The changes of inflammatory factors related indicators and cardiac function related indexes between the two groups were compared， and the overall clinical treatment effect was statistically analyzed. Results After intervention， the levels of hs-CRP， IL-6 and TNF-α in the observation group were lower than those in the control group(P<0.05). The NY-HA grade and BNP level in the cardiac function related indexes of the observation group were lower than those in the control group(P<0.05)， and the LVEF level in the observation group was higher than that of the control group(P<0.05). The effective rate of the observation group was significantly higher than that of the control group(P<0.05). Conclusion Azithromycin can effectively reduce the body's inflammatory response， improve cardiac function and improve overall clinical treatment for children with mycoplasma pneumonia.
[Key words] Azithromycin; Pediatric; Mycoplasmal pneumonia; Cardiac function
小兒支原体肺炎属于儿科最常见的呼吸道疾病，其发病机制复杂，治疗后容易反复，对患儿及其家属身心均造成负面影响，同时对患儿的生长发育亦有一定不利影响[1]。临床治疗则以抗病毒、抗感染为基础，结合对症支持治疗，如减少痰液分泌，减少气道痉挛，降低气道高反应性、维持水电解质酸碱平衡、加强营养支持等。已有的多项指南均提出小儿支原体肺炎需早诊断、早治疗，并提出多种药物可进行治疗[2]。虽然目前针对小儿支原体肺炎的药物种类多样，但其临床疗效、安全性等存在较大差异，尤其是抗菌药物方面，其中大环内酯类抗菌药物作为首选药物，亦有多种剂型可选择，为更好的提高本病的治疗效果，本研究主要探讨阿奇霉素对小儿支原体肺儿的临床效果，并分析其对患儿炎症反应因子、心功能相关指标及整体治疗效果的影响，现报道如下。, 百拇医药(项美萍 雷韵玉)
[关键词] 阿奇霉素;小儿;支原体肺炎;心功能
[中图分类号] R725.6 [文献标识码] B [文章编号] 1673-9701(2019)24-0057-03
[Abstract] Objective To investigate the effect of azithromycin on inflammatory response， cardiac function and therapeutic effect in children with mycoplasmal pneumonia. Methods 80 children with mycoplasmal pneumonia admitted to our hospital from January 2018 to January 2019 were enrolled. According to the random number method， they were divided into two groups， with 40 cases in each group. All patients underwent symptomatic supportive treatment. The control group received erythromycin， and the observation group used azithromycin. Both groups received continuous treatment for two weeks as a course of treatment. A one-month outpatient follow-up was performed. The changes of inflammatory factors related indicators and cardiac function related indexes between the two groups were compared， and the overall clinical treatment effect was statistically analyzed. Results After intervention， the levels of hs-CRP， IL-6 and TNF-α in the observation group were lower than those in the control group(P<0.05). The NY-HA grade and BNP level in the cardiac function related indexes of the observation group were lower than those in the control group(P<0.05)， and the LVEF level in the observation group was higher than that of the control group(P<0.05). The effective rate of the observation group was significantly higher than that of the control group(P<0.05). Conclusion Azithromycin can effectively reduce the body's inflammatory response， improve cardiac function and improve overall clinical treatment for children with mycoplasma pneumonia.
[Key words] Azithromycin; Pediatric; Mycoplasmal pneumonia; Cardiac function
小兒支原体肺炎属于儿科最常见的呼吸道疾病，其发病机制复杂，治疗后容易反复，对患儿及其家属身心均造成负面影响，同时对患儿的生长发育亦有一定不利影响[1]。临床治疗则以抗病毒、抗感染为基础，结合对症支持治疗，如减少痰液分泌，减少气道痉挛，降低气道高反应性、维持水电解质酸碱平衡、加强营养支持等。已有的多项指南均提出小儿支原体肺炎需早诊断、早治疗，并提出多种药物可进行治疗[2]。虽然目前针对小儿支原体肺炎的药物种类多样，但其临床疗效、安全性等存在较大差异，尤其是抗菌药物方面，其中大环内酯类抗菌药物作为首选药物，亦有多种剂型可选择，为更好的提高本病的治疗效果，本研究主要探讨阿奇霉素对小儿支原体肺儿的临床效果，并分析其对患儿炎症反应因子、心功能相关指标及整体治疗效果的影响，现报道如下。, 百拇医药(项美萍 雷韵玉)