阿尔茨海默病患者外周血中性粒细胞/淋巴细胞比值、血清C反应蛋白及白介素6水平变化及其临床意义(1)
[摘要] 目的 探討阿尔茨海默病(AD)患者外周血中性粒细胞/淋巴细胞比值(NLR)、血清C反应蛋白(CRP)及白介素6(IL-6)水平变化及其临床意义。 方法 选取 2016年1月～2018年12月我院收治的AD患者68例作为研究对象(AD组)，同期选取血管性痴呆患者30例作为对照组(VD组)，同时选取在本院体检健康老年人30例作为健康对照组。根据临床痴呆量表将AD患者分为轻度组、中度组和重度组。比较各组NLR、CRP及IL-6水平，并对结果进行Pearson相关性分析。 结果 AD组患者CRP及IL-6水平显著高于VD组和健康对照组，差异有统计学意义(P<0.05)，AD组与VD组患者外周血NLR水平显著高于健康对照组(P<0.05)，但两组间NLR水平比较，差异无统计学意义(P>0.05)。不同病情的AD亚组CRP及IL-6水平比较，重度组>中度组>轻度组，差异均有统计学意义(P<0.05);NLR各组间比较，差异无统计学意义(P>0.05)。Pearson相关性分析表明，AD患者NLR与CRP和IL-6呈正相关(r=0.457、0.762，P<0.05)。 结论 AD患者NLR、血清CRP及IL-6水平升高，且随着疾病的发展血清CRP及IL-6水平出现异常升高，三者可能参与了AD的发病过程，检测NLR与CRP和IL-6水平对评估及治疗AD具有一定参考价值。
[关键词] 阿尔茨海默病;中性粒细胞/淋巴细胞比值;C反应蛋白质;白介素6
[中图分类号] R743.3 [文献标识码] A [文章编号] 1673-9701(2020)26-0020-03
[Abstract] Objective To explore the changes of neutrophil/lymphocyte ratio(NLR)， serum C-reactive protein(CRP) and interleukin-6(IL-6) levels in peripheral blood of patients with Alzheimer's disease(AD) and their clinical significance. Methods A total of 68 patients with AD admitted to our hospital from January 2016 to December 2018 were selected as study subjects(AD group)， and 30 patients with vascular dementia were selected as control group(VD group)， and 30 healthy elderly patients in our hospital were selected as healthy control group. AD patients were divided into mild group， moderate group and severe group according to the clinical dementia scale. The levels of NLR， CRP and IL-6 in each group were compared. Pearson correlation analysis of the results was conducted. Results The levels of CRP and IL-6 in AD group were significantly higher than those in VD group and healthy control group(P<0.05). The level of NLR in peripheral blood of patients in AD group and VD group was significantly higher than that of healthy control group(P<0.05)， but there was no statistically significant difference between the two groups(P>0.05). The levels of CRP and IL-6 in the severe subgroup were higher than those in the moderate subgroup， and the levels in the moderate subgroup were higher than those of the mild subgroup， and the differences were statistically significant(P<0.05). There were no statistically significant differences among the NLR groups(P>0.05). Pearson correlation analysis showed that the NLR of AD patients was positively correlated with CRP and IL-6(r=0.457， 0.762， P<0.05). Conclusion The levels of NLR， CRP and IL-6 in peripheral blood of AD patients increased， and with the development of the disease， serum CRP and IL-6 levels increased abnormally， which may participate in the pathogenesis of AD. detection of NLR， CRP and IL-6 levels has certain reference value for the evaluation and treatment of AD., http://www.100md.com(杜更胜)
[关键词] 阿尔茨海默病;中性粒细胞/淋巴细胞比值;C反应蛋白质;白介素6
[中图分类号] R743.3 [文献标识码] A [文章编号] 1673-9701(2020)26-0020-03
[Abstract] Objective To explore the changes of neutrophil/lymphocyte ratio(NLR)， serum C-reactive protein(CRP) and interleukin-6(IL-6) levels in peripheral blood of patients with Alzheimer's disease(AD) and their clinical significance. Methods A total of 68 patients with AD admitted to our hospital from January 2016 to December 2018 were selected as study subjects(AD group)， and 30 patients with vascular dementia were selected as control group(VD group)， and 30 healthy elderly patients in our hospital were selected as healthy control group. AD patients were divided into mild group， moderate group and severe group according to the clinical dementia scale. The levels of NLR， CRP and IL-6 in each group were compared. Pearson correlation analysis of the results was conducted. Results The levels of CRP and IL-6 in AD group were significantly higher than those in VD group and healthy control group(P<0.05). The level of NLR in peripheral blood of patients in AD group and VD group was significantly higher than that of healthy control group(P<0.05)， but there was no statistically significant difference between the two groups(P>0.05). The levels of CRP and IL-6 in the severe subgroup were higher than those in the moderate subgroup， and the levels in the moderate subgroup were higher than those of the mild subgroup， and the differences were statistically significant(P<0.05). There were no statistically significant differences among the NLR groups(P>0.05). Pearson correlation analysis showed that the NLR of AD patients was positively correlated with CRP and IL-6(r=0.457， 0.762， P<0.05). Conclusion The levels of NLR， CRP and IL-6 in peripheral blood of AD patients increased， and with the development of the disease， serum CRP and IL-6 levels increased abnormally， which may participate in the pathogenesis of AD. detection of NLR， CRP and IL-6 levels has certain reference value for the evaluation and treatment of AD., http://www.100md.com(杜更胜)