自体血清治疗角膜深层异物剔除的术后疗效观察(1)
[摘要] 目的 探究自体血清对角膜深层异物剔除术后角膜恢复的影响。 方法 选取2018年5月～2019年4月本院门诊收治的80例角膜深层异物患者进行研究，随机分为对照组(n=40)和观察组(n=40)，对照组给予广谱抗生素常规治疗，观察组给予自体血清和广谱抗生素联合治疗，比较两组临床疗效、治疗后角膜水肿情况、荧光素染色情况和不良反应发生率。 结果 治疗后观察组患者的临床疗效总有效率(85.00%)明显高于对照组(65.00%)，差异有统计学意义(χ2=4.267，P=0.039);治疗后观察组角膜水肿情况优于对照组，差异有统计学意义(Z=2.315，P=0.021);治疗后观察组荧光素染色评分显著低于对照组，差异有统计学意义(t=9.817，P=0.000);观察组总不良反应发生率(5.00%)与对照组(5.00%)比较，差异无统计学意义(χ2=0.000，P=1.000)。 结论 自体血清可促进角膜上皮修复，对角膜深层异物剔除术后恢复疗效显著，且安全无副作用，在临床上有较高的应用价值。
[关键词] 自体血清;角膜深层异物剔除;术后疗效;荧光素染色评分
[中图分类号] R772.2 [文献标识码] B [文章编号] 1673-9701(2020)27-0081-04
[Abstract] Objective To explore the effect of self serum on corneal recovery after corneal deep foreign body removal. Methods Eighty patients with deep corneal foreign body admitted to our hospital from May 2018 to April 2019 were randomly divided into the control group(n=40) and the observation group(n=40). The control group was given broad-spectrum antibiotics for routine medication， and the observation group was given a combination of their self serum and broad-spectrum antibiotics. The clinical efficacy， corneal edema after treatment， fluorescein staining， and incidence of adverse reactions after treatment between two groups were compared. Results The total effective rate of the clinical efficacy of the observation group after treatment(85.00%) was significantly higher than that of the control group(65.00%)， and the difference was statistically significant(χ2=4.267， P=0.039). The edema after treatment was better in the observation group than in the control group， and the difference was statistically significant(Z=2.315， P=0.021). The fluorescein staining score was significantly lower in the observation group than that in the control group after treatment， and the difference was statistically significant(t=9.817， P=0.000). There was no significant difference in incidence rate of total adverse reactions between the observation group(5.00%) and the control group(5.00%)， (χ2=0.000， P=1.000). Conclusion Self serum can promote corneal epithelial repair， and has a significant recovery effect after corneal deep foreign body removal. It has the characteristics of safety and no side effects， and has high clinical application value.
[Key words] Self serum; Corneal deep foreign body removal; Postoperative efficacy; Fluorescein staining score
角膜異物是临床常见的眼科急症，该病是指生活中的灰尘、铁屑及风沙等异物进入眼中，附着在角膜表面和(或)嵌入角膜深处，对眼部产生不同程度的刺激，使患者出现畏光、眼内异物感、眼红、流泪和眼痛等症状的疾病，一般多见于风沙较大的地区和重工业区，若处理不及时或处理不当，原有的损伤可能进一步扩大，还有可能继发不同程度的角膜感染，轻则形成角膜云翳影响患者视力，重则造成失明等严重后果，影响患者的正常生活和工作[1-2]。深层角膜异物患者一般需尽快行角膜异物剔除术治疗，该术可有效剔除角膜异物，缓解患者痛苦，但手术会在一定程度上损伤患者角膜，导致眼部抗感染能力差，更不利于角膜上皮恢复，单行异物剔除手术治疗效果不佳，预后差，因此术后给予患者有效的干预措施，增强患者抗感染能力，促进角膜上皮恢复是临床手术效果的关键[3-4]。现阶段，临床上术后后续治疗药物多以广谱抗生素为主，但单一用药术后角膜上皮恢复效果不佳[5]。自体血清中含有大量的维生素和细胞因子，能为眼表皮细胞生长修复提供所需的营养物质[6]。本研究选取2018年5月～2019年4月本院门诊收治的80例角膜深层异物患者，探究自体血清联合广谱抗生素治疗的临床效果，现报道如下。, 百拇医药(李燕霞 汪根娥 许淑华)
[关键词] 自体血清;角膜深层异物剔除;术后疗效;荧光素染色评分
[中图分类号] R772.2 [文献标识码] B [文章编号] 1673-9701(2020)27-0081-04
[Abstract] Objective To explore the effect of self serum on corneal recovery after corneal deep foreign body removal. Methods Eighty patients with deep corneal foreign body admitted to our hospital from May 2018 to April 2019 were randomly divided into the control group(n=40) and the observation group(n=40). The control group was given broad-spectrum antibiotics for routine medication， and the observation group was given a combination of their self serum and broad-spectrum antibiotics. The clinical efficacy， corneal edema after treatment， fluorescein staining， and incidence of adverse reactions after treatment between two groups were compared. Results The total effective rate of the clinical efficacy of the observation group after treatment(85.00%) was significantly higher than that of the control group(65.00%)， and the difference was statistically significant(χ2=4.267， P=0.039). The edema after treatment was better in the observation group than in the control group， and the difference was statistically significant(Z=2.315， P=0.021). The fluorescein staining score was significantly lower in the observation group than that in the control group after treatment， and the difference was statistically significant(t=9.817， P=0.000). There was no significant difference in incidence rate of total adverse reactions between the observation group(5.00%) and the control group(5.00%)， (χ2=0.000， P=1.000). Conclusion Self serum can promote corneal epithelial repair， and has a significant recovery effect after corneal deep foreign body removal. It has the characteristics of safety and no side effects， and has high clinical application value.
[Key words] Self serum; Corneal deep foreign body removal; Postoperative efficacy; Fluorescein staining score
角膜異物是临床常见的眼科急症，该病是指生活中的灰尘、铁屑及风沙等异物进入眼中，附着在角膜表面和(或)嵌入角膜深处，对眼部产生不同程度的刺激，使患者出现畏光、眼内异物感、眼红、流泪和眼痛等症状的疾病，一般多见于风沙较大的地区和重工业区，若处理不及时或处理不当，原有的损伤可能进一步扩大，还有可能继发不同程度的角膜感染，轻则形成角膜云翳影响患者视力，重则造成失明等严重后果，影响患者的正常生活和工作[1-2]。深层角膜异物患者一般需尽快行角膜异物剔除术治疗，该术可有效剔除角膜异物，缓解患者痛苦，但手术会在一定程度上损伤患者角膜，导致眼部抗感染能力差，更不利于角膜上皮恢复，单行异物剔除手术治疗效果不佳，预后差，因此术后给予患者有效的干预措施，增强患者抗感染能力，促进角膜上皮恢复是临床手术效果的关键[3-4]。现阶段，临床上术后后续治疗药物多以广谱抗生素为主，但单一用药术后角膜上皮恢复效果不佳[5]。自体血清中含有大量的维生素和细胞因子，能为眼表皮细胞生长修复提供所需的营养物质[6]。本研究选取2018年5月～2019年4月本院门诊收治的80例角膜深层异物患者，探究自体血清联合广谱抗生素治疗的临床效果，现报道如下。, 百拇医药(李燕霞 汪根娥 许淑华)