初诊糖尿病及糖尿病前期早相胰岛分泌功能情况的调查(1)
[摘要] 目的 探讨初诊糖尿病及糖尿病前期患者早相胰岛分泌功能的情况及其影响因素。 方法 2019年1～6月从我院体检中心随机抽取龙岩市社区500例既往无糖尿病史的体检居民进行调查，测定其空腹及OGTT试验0.5 h、2 h血糖、胰岛素、血脂，记录BMI、腰臀比(WHR)、年龄、平均收缩压(SBP)、平均舒张压(DBP)，计算早相胰岛分泌功能指数(△I30/△G30)、胰岛素抵抗指数(HOMA-IR)。 结果 早相胰岛分泌功能，初诊DM组IGT+IFG组>IFG组> IGT组>NGT组。多元逐步回归分析显示，WHR、SBP、TG、HOMA-IR与△I30/△G30呈显著负相关，HLD-C与△I30/△G30呈显著正相关(P<0.05);BMI、WHR、SBP、LDL-C与HOMA-IR呈显著正相关，而HLD-C与HOMA-IR呈显著负相关。 结论 IFG、IGT、IGT+IFG、初诊DM的早相胰岛分泌功能呈进行性受损，其与胰岛素抵抗水平有关，控制BMI、WHR、血脂、收缩压达标具有重要意义。
[关键词] 糖尿病;糖尿病前期;早相胰岛分泌功能;胰岛素抵抗
[中图分类号] R587.1 [文献标识码] B [文章编号] 1673-9701(2020)31-0138-04
[Abstract] Objective To explore the early-phase pancreatic islet secretory function and its influencing factors in newly diagnosed diabetes and prediabetes patients. Methods A total of 500 residents in the community of Longyan who had no history of diabetes from January 2019 to June 2019 were randomly selected from the physical examination center of our hospital for investigation. Their fasting and OGTT test 0.5 h， 2 h blood glucose， insulin， and blood lipids were measured. The BMI， Waist-hip ratio(WHR)， age， mean systolic blood pressure(SBP)， and mean diastolic blood pressure(DBP) were recorded. The early phase pancreatic islet secretory function index(△I30/△G30)， insulin resistance index(HOMA-IR) were calculated. Results Early-phase islet secretion function， newly diagnosed DM groupIGT+IFG group>IFG group>IGT group>NGT group. Multiple stepwise regression analysis showed that WHR， SBP， TG， HOMA-IR were significantly negatively correlated with △I30/△G30， and HLD-C was significantly positively correlated with △I30/△G30(P<0.05); BMI， WHR， SBP， LDL-C has a significant positive correlation with HOMA-IR， while HLD-C has a significant negative correlation with HOMA-IR. Conclusion IFG， IGT， IGT+IFG， and newly diagnosed DM have progressively impaired pancreatic islet secretion in the early phase， which is related to the level of insulin resistance. It is of great significance to control BMI， WHR， blood lipids， and systolic blood pressure.
[Key words] Diabetes; Pre-diabetes; Early-phase pancreatic islet secretion; Insulin resistance
目前我國糖尿病和糖尿病前期的发病率均逐年升高，因此对其发病的危险因素进行深入分析显得尤为重要。众所周知，胰岛 β 细胞功能损害和胰岛素抵抗是 2 型糖尿病发病的核心病理生理机制，有研究表明[1]早相胰岛素分泌缺陷是胰岛β细胞功能损害最早也是最主要的特征，早相分泌功能降低在糖耐量受损阶段或2型糖尿病发病的早期即可出现。因此早期发现早相胰岛素分泌缺陷在糖尿病一级预防中起重要作用。本研究旨在通过对福建省龙岩市2019年1～6月500名社区居民进行调查，以了解初诊糖尿病及糖尿病前期患者早相胰岛分泌功能及胰岛素抵抗的情况，并探讨其可能相关的影响因素，以期指导城镇居民进行糖尿病的一级预防。, http://www.100md.com(黄蓉 丘水林 邱秀萍)
[关键词] 糖尿病;糖尿病前期;早相胰岛分泌功能;胰岛素抵抗
[中图分类号] R587.1 [文献标识码] B [文章编号] 1673-9701(2020)31-0138-04
[Abstract] Objective To explore the early-phase pancreatic islet secretory function and its influencing factors in newly diagnosed diabetes and prediabetes patients. Methods A total of 500 residents in the community of Longyan who had no history of diabetes from January 2019 to June 2019 were randomly selected from the physical examination center of our hospital for investigation. Their fasting and OGTT test 0.5 h， 2 h blood glucose， insulin， and blood lipids were measured. The BMI， Waist-hip ratio(WHR)， age， mean systolic blood pressure(SBP)， and mean diastolic blood pressure(DBP) were recorded. The early phase pancreatic islet secretory function index(△I30/△G30)， insulin resistance index(HOMA-IR) were calculated. Results Early-phase islet secretion function， newly diagnosed DM group
[Key words] Diabetes; Pre-diabetes; Early-phase pancreatic islet secretion; Insulin resistance
目前我國糖尿病和糖尿病前期的发病率均逐年升高，因此对其发病的危险因素进行深入分析显得尤为重要。众所周知，胰岛 β 细胞功能损害和胰岛素抵抗是 2 型糖尿病发病的核心病理生理机制，有研究表明[1]早相胰岛素分泌缺陷是胰岛β细胞功能损害最早也是最主要的特征，早相分泌功能降低在糖耐量受损阶段或2型糖尿病发病的早期即可出现。因此早期发现早相胰岛素分泌缺陷在糖尿病一级预防中起重要作用。本研究旨在通过对福建省龙岩市2019年1～6月500名社区居民进行调查，以了解初诊糖尿病及糖尿病前期患者早相胰岛分泌功能及胰岛素抵抗的情况，并探讨其可能相关的影响因素，以期指导城镇居民进行糖尿病的一级预防。, http://www.100md.com(黄蓉 丘水林 邱秀萍)