王雯雯 应丽梅 丁笑笑 陈建霖 孙建国

    [摘要] 泌乳素(Prolactin，PRL)又称催乳素，由垂体前叶的催乳素细胞合成和分泌。其合成与分泌受下丘脑多巴胺能途径的调节。高泌乳素血症是指外周血泌乳素水平升高。泌乳素升高原因可归结于生理性、药物性、病理性和特发性等。目前以高泌乳素血症为首发表现的急性淋巴细胞白血病(Acute lymphoblastic leukemia，ALL)病例国内尚未见报道。本研究报道1例以高泌乳素血症为首发表现的急性淋巴细胞白血病并探讨对此类疾病的诊治。

    [关键词] 高泌乳素血症;急性淋巴细胞白血病;泌乳素;肿瘤;治疗

    [中图分类号] R733.71? ? ? ? ? [文献标识码] C? ? ? ? ? [文章编号] 1673-9701(2020)32-0162-04

    [Abstract] Prolactin(PRL) is synthesized and secreted by the prolactin cells of the anterior pituitary gland. Its synthesis and secretion are regulated by the hypothalamic dopaminergic pathway. Hyperprolactinemia refers to increased levels of peripheral blood prolactin. The cause of elevated prolactin can be attributed to physiological， drug， pathological and idiopathic. At present， acute lymphoblastic leukemia(ALL) cases with hyperprolactinemia as the first manifestation have not been reported in China. This study report a case of acute lymphoblastic leukemia with hyperprolactinemia as the first manifestation and discuss the diagnosis and treatment of such diseases. ......