遇建东

    [摘要] 目的 探讨产前四维超声在胎儿先天性心脏畸形(CHD)中的应用价值。 方法 收集2016年4月～2019年5月在我院进行胎儿超声心动图筛查的胎儿CHD高危孕妇680例为观察对象，均接受产前四维超声检查，以引产病理/随访结果作为金标准，评估产前四维超声对胎儿CHD的检出率及诊断价值。 结果 680例高危因素孕妇经引产病理/随访结果证实为CHD者67例，发病率为9.85%;产前四维超声检出的胎儿CHD 64例，检出率为95.52%，二者比较差异无统计学意义(χ2=3.069，P=0.080);产前四维超声对胎儿CHD诊断的阳性预测值为98.44%，阴性预测值为99.35%，灵敏度为94.03%，特异度为99.84%，准确率为99.26%;产前四维超声对胎儿CHD诊断的ROC曲线下面积为0.841(95%CI：0.790～0.892)。 结论 产前四维超声在胎儿先天性心脏畸形中具有较高的检出率，且诊断灵敏度、特异度、准确率均较高，值得推广。

    [关键词] 产前检查;四维超声;先天性心脏畸形;检出率

    [中图分类号] R445.1? ? ? ? ? [文献标识码] B? ? ? ? ? [文章编号] 1673-9701(2020)35-0104-04

    [Abstract] Objective To explore the application value of prenatal four-dimensional ultrasound in fetal congenital heart defects(CHD). Methods A total of 680 pregnant women with high risk of fetal CHD who underwent fetal echocardiography screening in our hospital from April 2016 to May 2019 were collected as observation objects. All of them underwent prenatal four-dimensional ultrasound examination. Using pathological/follow-up results of induction of labor as the gold standard ......