李丽娟 师凤华 谭木秀 刘凤鸣

    [摘要] 肠道菌群失调与多种系统疾病的发生发展密切相关，研究证明膳食纤维在肠道菌群结构和功能方面具有重要调节作用，有利于维持肠道菌群动态平衡。膳食纤维为肠道菌群提供生长代谢底物，且优化了菌群代谢，肠道菌群通过酵解在小肠中不能被消化吸收的膳食纤维，产生的代谢产物参与机体多种信号调节机制，从而影响宿主生理病理改变。本文将对近段时间关于膳食纤维调节肠道菌群的作用机制进行综述，以期为更有效利用膳食纤维，优化肠道菌群代谢，防治疾病提供更多的参考依据。

    [关键词] 膳食纤维;肠道菌群;短链脂肪酸;机制

    [中图分类号] R151? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2020)36-0188-05

    [Abstract] Intestinal flora imbalance is closely related to the occurrence and development of a variety of systemic diseases. Studies have shown that dietary fiber plays an important regulatory role in the structure and function of intestinal flora， which is conducive to maintaining the dynamic balance of intestinal flora. Dietary fiber provides growth and metabolism substrate for intestinal flora， and optimizes its metabolism. Intestinal flora produces dietary fiber that cannot be digested and absorbed in the small intestine through fermentation， and the metabolites produced participate in various signal regulation mechanisms of the body， thus affecting physiological and pathological changes of the host. This paper will review the mechanism of dietary fiber regulating intestinal flora in recent years to provide more references for more effective use of dietary fiber ......