周卫 刘克洪 胡晓华

    [摘要] 意识障碍(Disorder of consciousness，DOC)包括無反应觉醒综合征(Unresponsive wakefulness syndrome，UWS)和最小意识状态(Minimal state of consciousness，MCS)。近年来意识障碍患者的意识转归成为本专业的研究热点。意识障碍患者意识转归的发生可能是自发出现的，也可能是药物、电或磁等因素刺激引起的。药物治疗目前是治疗意识障碍比较常用的治疗手段，且相关研究较多。因此，本文从药物作用机制以及临床疗效等方面综合阐述了唑吡坦、金刚烷胺、巴氯芬等西药和安宫牛黄丸、醒脑静等中成药对意识障碍患者意识好转的作用。

    [关键词] 意识障碍;唑吡坦;金刚烷胺;药物治疗

    [Abstract] Disorder of consciousness(DOC) includes unresponsive wakefulness syndrome(UWS) and minimal state of consciousness(MCS). In recent years， the consciousness outcome of patients with DOC has become a research hotspot in this field. The occurrence of consciousness outcome of patients with DOC may happen spontaneously， or may be caused by the stimulation of drugs， electricity or magnetism. At present， drug therapy is a commonly used treatment for DOC， and there are many related researches. Therefore， the functions of western medicines such as zolpidem， amantadine and baclofen， and Chinese patent medicines such as Angong Niuhuang pill and Xingnaojing on improving consciousness of patients with DOC from the aspects of drug action mechanism and clinical therapeutic efficacy were comprehensively expounded in this paper. ......