李月翠 胡伟跃 徐象威 陈豪

    [摘要] 目的 探討活血软坚扶正方联合抗病毒治疗气虚血瘀证型HBeAg阴性慢性乙型肝炎(CHB)患者肝纤维化的疗效。 方法 选取2019年1—12月我院感染科收治的80例HBeAg阴性CHB患者进行研究。采用随机数字表法分为观察组和对照组，每组各40例。对照组采用抗病毒治疗，观察组在对照组基础上加用活血软坚扶正方治疗。治疗36周，观察两组中医证候积分、临床疗效、肝纤维化、肝功能及不良反应。 结果 治疗后，观察组中医证候积分低于对照组，差异有统计学意义(P0.05). In the observation group，there were 4 patients with nausea and 3 patients with headache and dizziness，all of whom were mild and no special treatment was needed. Conclusion Huoxue Ruanjian Fuzheng Recipe combined with antiviral treatment for patients with HBeAg-negative CHB patients with qi deficiency and blood stasis syndrome has a good clinical effect， which can effectively improve clinical symptoms and liver fibrosis indicators， relieve liver function，and has fewer adverse reactions.

    [Key words] Huoxue Ruanjian Fuzheng Recipe; Antiviral; Qi deficiency and blood stasis syndrome; HBeAg negative; CHB; Liver fibrosis ......