阿立哌唑联合帕罗西汀治疗精神分裂症后抑郁的临床疗效
刘颖 朱永[摘要] 目的 探討阿立哌唑联合帕罗西汀治疗精神分裂症后抑郁的临床疗效。 方法 选择2019年1—12月在我院诊断治疗的精神分裂症后抑郁患者60例为研究对象,随机分为联合组与对照组,每组各30例。两组均给予阿立哌唑口服治疗,联合组在此基础上加用帕罗西汀治疗。比较两组治疗前后HAMD评分、PANSS评分及不良反应发生情况。 结果 治疗后4周及8周,两组HAMD评分均显著低于治疗前;联合组HAMD评分分别为(12.5±2.0)分、(8.4±1.3)分,显著低于对照组的(16.6±1.8)分、(11.5±1.6)分,差异有统计学意义(P0.05)。 结论 阿立哌唑联合帕罗西汀治疗精神分裂症后抑郁,可以改善患者的HAMD评分、PANSS阳性因子评分、阴性因子评分、一般精神病理学分及总分,并且不显著增加不良反应。
[关键词] 帕罗西汀;阿立哌唑;精神分裂症;抑郁
[中图分类号] R749.3? ? ? ? ? [文献标识码] B? ? ? ? ? [文章编号] 1673-9701(2021)06-0123-04
Clinical effect of aripiprazole combined with paroxetine in the treatment of post-schizophrenia depression
LIU Ying? ?ZHU Yong
1.Inpatient Department Pharmacy, Jiamusi Psychiatric Welfare Hospital in Heilongjiang Province, Jiamusi? ?154002, China; 2.The Sixth Ward, Jiamusi Psychiatric Welfare Hospital in Heilongjiang Province, Jiamusi? 154002, China
[Abstract] Objective To explore the clinical efficacy of aripiprazole combined with paroxetine in the treatment of post-schizophrenia depression. Methods A total of 60 patients with post-schizophrenia depression who were diagnosed and treated in our hospital from January to December 2019 were selected as the research subjects ......
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