陈茹茹 罗厚江 杨军

    [摘要] 肝素是一种广泛应用于临床的抗凝血药物，现已发现肝素的生物活性主要来源于其与数百种不同蛋白质的相互作用，因此，肝素除了具有抗凝作用外，还具有较强的抗炎、抗肿瘤、抗病毒、促进伤口愈合、抗贫血等药理特性。随着对肝素的深入研究，低分子量肝素被发现，与普通肝素相比，低分子量肝素具有较长的半衰期、更好的生物利用度，更少发生出血、过敏反应及肝素诱导的血小板减少症等不良反应。本文就低分子量肝素的作用机制及临床应用研究进展进行论述。

    [关键词] 低分子量肝素;作用机制;临床应用;普通肝素;研究进展

    [中图分类号] R720.5? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)06-0182-05

    Research progress on action mechanism and clinical application of low molecular weight heparin

    CHEN Ruru? ?LUO Houjiang? ?YANG Jun

    Department of Pediatrics， the Second Affiliated Hospital of Bengbu Medical College， Bengbu? ?233000， China

    [Abstract] Heparin is an anticoagulant drug widely used in clinic. It has been found that the biological activity of heparin mainly comes from its interaction with hundreds of different proteins. Therefore， besides anticoagulation， heparin also has strong pharmacological properties such as anti-inflammation， anti-tumor， anti-virus， promoting wound healing， and anti-anemia. With the in-depth study of heparin， low molecular weight heparin(LMWH) was discovered. Compared with ordinary heparin ......