王丽 张颖

    [摘要] 目的 觀察阿司匹林、硫酸氢氯吡格雷联合羟乙基淀粉治疗短暂性脑缺血发作(TIA)伴颅内血管狭窄近期疗效及安全性。 方法 收集2018年6月至2020年6月北部战区总医院神经内科确诊98例短暂性脑缺血发作伴颅内血管狭窄患者的临床资料。根据用药情况分为观察组(阿司匹林+硫酸氢氯吡格雷+羟乙基淀粉，n=48)与对照组(阿司匹林+硫酸氢氯吡格雷，n=50)。观察两组7 d内有效率及不良反应。 结果 观察组总有效率高于对照组(93.75% vs. 78.00%)，两组比较，差异有统计学意义(χ2=4.961，P=0.026)。观察组不良事件4例，对照组不良事件1例，差异无统计学意义(8.34% vs. 2.00%，χ2=0.932，P=0.334)。 结论 双抗联合羟乙基淀粉对TIA伴有颅内血管狭窄有效，且有良好的安全性。

    [关键词] 阿司匹林;硫酸氢氯吡格雷;短暂性脑缺血发作;羟乙基淀粉

    [中图分类号] R512.3? ? ? ? ? [文献标识码] B? ? ? ? ? [文章编号] 1673-9701(2021)09-0056-04

    The short-term efficacy of double antibodies combined with hydroxyethyl starch in the treatment of transient ischemic attack

    WANG Li1? ?ZHANG Ying2

    1.Department of Neurology， General Hospital of Northern Theater Command， Shenyang 110016， China; 2.Tieling Health Vocational College， Tieling? ?112008， China

    [Abstract] Objective To observe the short-term efficacy and safety of aspirin， clopidogrel hydrogen sulfate combined with hydroxyethyl starch in the treatment of transient ischemic attack(TIA) complicated with intracranial vascular stenosis. Methods The clinical data of 98 patients diagnosed as TIA complicated with intracranial vascular stenosis admitted to the department of neurology in the General Hospital of Northern Theater Command from June 2018 to June 2020 were collected. According to the medication ......