王秀峰

    [摘要] 目的 研究硝普钠联合米力农治疗心力衰竭(HF)患者的疗效及对患者IL-6、血浆NT-proBNP水平的影响。方法 选取2018年12月至2020年6月我院收治的HF患者198例，随机分为观察组和对照组，每组各99例。对照组采用硝普钠治疗，观察组在此基础上联合米力农治疗，比较两组临床疗效、心功能指标、血清IL-6、TNF-α水平及不良反应发生情况。 结果 观察组临床治疗总有效率为94.95%，高于对照组的84.85%，差异有统计学意义(P0.05);治疗后两组上述心功能指标均有所改善，观察组LVEF为(46.77±3.29)%、LVEDd为(57.46±1.24)mm、NT-proBNP為(328.64±15.88)pg/mL、6MWT为(372.64±16.79)min，明显优于对照组的(41.23±4.35)%、(58.76±0.64)mm、(672.97±16.79)pg/mL、(342.88±14.28)min，差异有统计学意义(P0.05);治疗后两组血清IL-6、TNF-α水平较治疗前下降，观察组IL-6为(1130.42±17.88)ng/L、TNF-α为(209.43±4.35)ng/L，均低于对照组的(1324.56±16.49)ng/L、(232.47±4.22)ng/L，差异有统计学意义(P0.05). After treatment， the LVEF (46.77±3.29)%， LVEDd (57.46±1.24) mm， NT-proBNP (328.64±15.88) pg/mL， and 6MWT (372.64±16.79) min in the observation group were significantly better than (41.23±4.35)%， (58.76±0.64) mm， (672.97±16.79) pg/mL， (342.88±14.28) min of the control group， the differences were statistically significant(P0.05). After treatment， IL-6 (1130.42±17.88) ng/L and TNF-α (209.43±4.35) ng/L in the observation group were significantly lower than (1324.56±16.49) ng/L and (232.47±4.22) ng/L in the control group ......