黎永祥 腾政杰 李梦瑶 寇雨顺 何亚丽 申进增 伊琳

    [摘要] 高血压肾损伤是临床常见病，也是高血压的严重并发症，随着高血压患者的增加及日趋年轻化，由此导致的肾脏损伤也在与日俱增，高血压肾损伤在全世界范围内发病率呈上升趋势，严重威胁着人类的健康和生存质量。原发性高血压长期控制不佳，特别是由于恶性高血压的控制失调，引起肾脏血流动力学改变，进而导致肾小球硬化、肾小管萎缩、肾间质纤维化，并逐渐出现肾功能不全的临床表现，即为高血压肾损伤。研究发现，非编码RNA在高血压及高血压肾损伤中存在特异性表达并发挥重要作用，为高血压肾损害的机制研究及靶向治疗提供新思路，本文就高血压肾损伤中的非编码RNA的特异性表达、作用机制、作用靶点的研究进展作出如下综述。

    [关键词] 非编码RNA;高血压;高血压肾损伤;研究进展

    [中图分类号] R544.1? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)10-0187-06

    Research progress of non-coding RNA in hypertension and hypertensive renal injury

    LI Yongxiang1? ?TENG Zhengjie2? ?LI Mengyao1? ?KOU Yushun1? ?HE Yali1? ?SHEN Jinzeng1? ?YI Lin1

    1.School of Integrated Chinese and Western Medicine， Gansu University of Chinese Medicine， Lanzhou? ?730000， China; 2.Department of Cardiovascular Medicine， Affiliated Hospital of Gansu University of Chinese Medicine， Lanzhou? ?730000， China

    [Abstract] Hypertensive kidney injury is a common clinical disease and a serious complication of hypertension. With the increase in the number of hypertensive patients and the decrease in the age of onset， the kidney injury caused by this is also increasing daily. The incidence of hypertensive kidney injury is increasing worldwide ......