吴志敏 胡万华 赵娜

    [摘要] 目的 觀察解郁1号方联合八段锦干预脑卒中后抑郁(PSD)的临床疗效及作用机制。方法 研究对象为2019年1—12月在温州市中医院神经内科住院的80例PSD患者，随机分成试验组和对照组，每组40例。对照组予盐酸舍曲林治疗，试验组予解郁1号方联合八段锦治疗，治疗后观察两组临床疗效并进行比较。分别采用汉密尔顿抑郁量表(HAMD)、症状自评量表(SCL-90)对PSD患者抑郁情况及相关心理状况进行评价，两组患者治疗前、治疗4周后分别评价1次;治疗前、治疗4周后检测患者血清中5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)水平。 结果 治疗4周后，试验组患者的HAMD、SCL-90躯体化、抑郁、其他(饮食睡眠)因子均低于对照组，差异均有统计学意义(P0.05)。 结论 解郁1号方联合八段锦治疗PSD的临床疗效显著，可能与提高患者5-HT、BDNF的表达有关。

    [关键词] 八段锦;解郁1号方;脑卒中后抑郁;临床观察

    [中图分类号] R749.4;R743.3? ? ? ? ? [文献标识码] B? ? ? ? ? [文章编号] 1673-9701(2021)11-0134-04

    Clinical observation of JieYu No.1 Recipe combined with Baduanjin in treatment of post-stroke depression

    WU Zhimin? ?HU Wanhua? ?ZHAO Na

    Department of Neurology， Wenzhou Hospital of Traditional Chinese Medicine in Zhejiang Province， Wenzhou? ?325000， China

    [Abstract] Objective To observe the clinical efficacy and mechanism of Jieyu No.1 Recipe combined with Baduanjin in intervention of post-stroke depression(PSD). Methods A total of 80 patients with PSD who were hospitalized in the Department of Neurology， Wenzhou Hospital of Traditional Chinese Medicine from January to December 2019 were selected as the study objects. They were randomly divided into the experimental group and the control group ......