祝宁宁 胡慧瑾 赵越超 叶宝东

    [摘要] 自身免疫性溶血性贫血(Autoimmune hemolytic anemia，AIHA)是异基因造血干细胞移植术(Allogeneic hematopoietic stem cell transplantation，allo-HSCT)后一种少见但严重的并发症。移植后早期出现AIHA的机制目前尚未阐明，治疗手段有限，往往预后不佳。本文收集并分析了我院收治的1例原发病为骨髓增生异常综合征(myelodysplastic syndrome，MDS)行allo-HSCT后发生AIHA的临床特点、诊治方法、治疗选择和转归，并结合文献分析总结其临床特征，以期了解allo-HSCT后 AIHA的发病机制及防治。

    [关键词] 异基因造血干细胞移植;贫血;溶血性;自身免疫性;利妥昔单抗

    [中图分类号] R556.6? ? ? ? ? [文献标识码] C? ? ? ? ? [文章编号] 1673-9701(2021)11-0142-05

    Rituximab in the treatment of early complicated autoimmune hemolytic anemia after hematopoietic stem cell transplantation： A case report and? literature review

    ZHU Ningning1， 2? ?HU Huijin2? ?ZHAO Yuechao2? ?YE Baodong1， 2

    1.The First Clinical College of Zhejiang Chinese Medical University， Hangzhou? ?310053， China; 2. Department of Hematology， The First Affiliated Hospital of Zhejiang Chinese Medical University， Hangzhou? ?310006， China

    [Abstract] Autoimmune hemolytic anemia(AIHA) is a rare but serious complication after allogeneic hematopoietic stem cell transplantation(allo-HSCT). The mechanism of early occurrence of AIHA after transplantation has not yet been elucidated ......