徐静琳 孔祥静 韩颖敏 陶海英

    [关键词] 舒洛地特;微小RNA-27a;自噬;糖尿病肾病;足细胞损伤

    [中图分类号] R285.5;R587.205? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)14-0039-06

    Mechanism research of sulodexide in regulating miR-27a-mediated autophagy in regulation of podocyte injury in diabetic nephropathy

    XU Jinglin1? ?KONG Xiangjing1? ?HAN Yingmin1? ?TAO Haiying2

    1.Department of Nephrology， the First People′s Hospital of Taizhou City in Zhejiang Province， Taizhou? ?318000， China; 2.Department of Endocrinology， the First People′s Hospital of Taizhou City in Zhejiang Province， Taizhou 318000， China

    [Abstract] Objective To analyze the mechanism of sulodexide in regulating microRNA-27a(miR-27a)-mediated autophagy in the regulation of podocyte injury in diabetic nephropathy. Methods Fifteen of the 45 rats were selected as the normal group without any treatment， and the remaining rats were used to establish a diabetic nephropathy rat model and randomly divided into the model group and the sulodexide group with 15 rats in each group. Rats in the sulodexide group were given intramuscular injection of sulodexide ......