菊轩 时雯雯 陈松 胡希文 董介正 朱春燕

    [關键词] 睡眠剥夺;氟西汀;抑郁;促肾上腺皮质激素;皮质酮

    [中图分类号] R852.5? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)16-0043-05

    Effects of sleep deprivation combined with fluoxetine on behavior and serum adrenocorticotropic hormone and corticosterone in depression model rats

    JU Xuan1? ?SHI Wenwen2? ?CHEN Song1? ?HU Xiwen1? ?DONG Jiezheng1? ?ZHU Chunyan1

    1.The Sixth Department of Psychiatry， Hangzhou Seventh People′s Hospital， Hangzhou 310013， China; 2.Department of Science and Education， Hangzhou Seventh People′s Hospital， Hangzhou? ?310013， China

    [Abstract] Objective To investigate the effect of sleep deprivation combined with fluoxetine on behavior， serum adrenocorticotropic hormone(ACTH) and corticosterone(CORT) in depression model rats and its possible mechanism. Methods Sixty adult SD male rats were divided into the normal control group (10 rats) and the stress model group (50 rats).The stress model group underwent 21 days of chronic mild unpredictable stress(CMUS) ......