司君增 王秀芹 杨艳红 邢晓玲 郑立峰 亓勤德 朱峻岭

    [关键词] ADAM10;基因多态性;阿尔茨海默病;整合素

    [中图分类号] R749.1? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)17-0001-03

    Study on correlation between ADAM10 gene polymorphism and Alzheimer′s disease

    SI Junzeng? ?WANG Xiuqin? ?YANG Yanhong? ?XING Xiaoling? ?ZHENG Lifeng? ?QI Qinde? ?ZHU Junling

    Department of Neurology， Ji′nan City People′s Hospital， Ji′nan People′s Hospital Affiliated to Shandong First Medical University， Ji′nan 271199， China

    [Abstract] Objective To explore the correlation between a disintegrin and metalloproteinase 10 gene (ADAM10) rs2305421 and rs653765 polymorphisms and the genetic susceptibility of northern Chinese Han population to Alzheimer′s disease (AD). Methods A total of 96 AD patients (the case group) and 102 healthy people (the control group) admitted to our hospital from January 2013 to May 2020 were matched in age and gender. The ADAM10 rs2305421 and rs653765 loci were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The distribution of genotype frequency and allele frequency between the case group and the control group was compared by chi-square test. The intensity analysis of single gene nucleotide polymorphism and AD risk was expressed by odds ratio (OR) and 95% confidence interval (95%CI). Results The genotype of ADAM10 rs2305421 locus in the case group was [46(47.92)%] ......