吴琦

    [关键词] 三叶青黄酮;STAT3信号通路;膀胱癌;细胞增殖;细胞凋亡

    [中图分类号] R735.7? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)17-0025-04

    Effect and mechanism research of cloverleaf flavonoids regulated STAT3 signaling pathway on proliferation and apoptosis of bladder cancer cells

    WU Qi

    Department of Urinary Surgery， the People's Hospital of Lishui City in Zhejiang Province， Lishui? ?323000， China

    [Abstract] Objective To analyze the effect and mechanism of cloverleaf flavonoids regulated STAT3 signaling pathway on the proliferation and apoptosis of bladder cancer cells. Methods Bladder cancer T24 cells were divided into the control group，the low-dose group and the high-dose group，and treated with the blank medium，50 μg/mL cloverleaf flavonoids and 100 μg/mL cloverleaf flavonoids， respectively. Flow cytometry was used to detect the cell apoptosis， and MTT method was used to detect the apoptosis inhibition rates of T24 cells. The levels of Caspase-3 ......