高聚伟 徐凯 冉冉 应吟吟

    [關键词] 龙葵碱;肝癌;免疫逃逸;Treg细胞

    [中图分类号] R285.5? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)18-0035-04

    Impacts of solanine on tumor immune escape mediated by Treg cells in hepatocellular carcinoma

    GAO Juwei? ?XU Kai? ?RAN Ran? ?YING Yinyin

    Department of Oncology， The Third Affiliated Hospital of Zhejiang Chinese Medical University， Hangzhou? ?310012， China

    [Abstract] Objective To research the impacts of solanine on hepatoma cells immune escape mediated by regulatory T cells (Treg cells) in hepatocarcinoma bearing mice and its action mechanism. Methods The mice model of H22 cell transplantation tumor was established and they were divided into the control group， the solanine group， the transforming growth factor-β1 (TGF-β1) inhibitor group and the solanine combined with TGF-β1 inhibitor group. After 14 days of treatment ......