于涛 龚海东 鉴玉波 袁婧 朱琳 梁欢 王闰 纪国敏 李海红 马丽秋

    [關键词] 高血压;基因多态性;药效学;脑出血

    [中图分类号] R743.34? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)23-0005-05

    Application effect of gene testing of antihypertensive drugs in hypertensive patients with cerebral hemorrhage

    YU Tao1? ?GONG Haidong1? ?JIAN Yubo1? ?YUAN Jing1? ?ZHU Lin1? ?LIANG Huan1? ?WANG Run1? ?JI Guomin1? ?LI Haihong2? ?MA Liqiu1

    1.Department of Neurosurgery， Hongqi Hospital Affiliated to Mudanjiang Medical University， Mudanjiang? ?157011， China; 2.Department of Gitical Care Medicine， Hongqi Hospital Affiliated to Mudanjiang Medical University， Mudanjiang? ?157011， China

    [Abstract] Objective To analyze the polymorphisms of anti-hypertensive-related genes in hypertensive patients with cerebral hemorrhage and distribution characteristics in the population and explore the clinical effect of anti-hypertensive gene testing on rational drug intervention in hypertensive patients with cerebral hemorrhage. Methods A total of 284 stroke patients who had a history of hypertension or were diagnosed with hypertension at the time of discharge and were hospitalized in the Department of Neurosurgery of Hongqi Hospital of Mudanjiang Medical University from January 2018 to September 2020 were selected. They were divided into the gene group (n=233) and the control group (n=51) ......