和庆章 王桂良 邱 萍 徐林芳 龚敏 付云辉 韩明 文剑波

    [關键词] 胆管癌;rHAd-P53;碘125;Bcl2;Bax

    [中图分类号] R735.2? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)29-0044-05

    Impacts of recombinant human adenovirus P53 and iodine-125 particles regulating Bax and Bcl2 on proliferation and apoptosis of transplanted tumor of cholangiocarcinoma in nude mice

    HE Qingzhang? ?WANG Guiliang? ?QIU Ping? ?XU Linfang? ?GONG Min? ?FU Yunhui? ?HAN Ming? ?WEN Jianbo

    Department of Gastroenterology， Pingxiang Hospital Affiliated to Gannan Medical University， Pingxiang? ?337000， China

    [Abstract] Objective To explore the impacts of recombinant human adenovirus P53(rHAd-P53) and iodine-125 particles regulating Bax and Bcl2 on proliferation and apoptosis of transplanted tumor of cholangiocarcinoma in nude mice. Methods Human cholangiocarcinoma cells were selected to establish human cholangiocarcinoma xenograft model in nude mice. A total of 48 nude mice were divided into the blank control group ......