田钟元 安秀琴 刘近春

    [摘要] 代谢相关脂肪性肝病(MAFLD)/非酒精性脂肪性肝病(NAFLD)已经逐渐上升为全球慢性肝病的首位。导致本病发生和发展的机制一直是众多学者和临床医师关注的重点。巨噬细胞作为参与MAFLD发病的重要细胞之一，在MAFLD的发病机制及疾病进展中占有重要的地位。本文针对肝脏巨噬细胞的来源及分类、巨噬细胞与MAFLD疾病谱的相关性，及巨噬细胞与MAFLD的发病机制如炎症、免疫应答、胰岛素抵抗(IR)、脂质代谢、肠道菌群、肥胖等的相关性进行总结，以期为临床开发以巨噬细胞为靶点的药物提供新的思路。

    [关键词] 代谢相关脂肪性肝病;非酒精性脂肪性肝病;巨噬细胞;机制

    [中图分类号] R575? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2021)34-0183-05

    [Abstract] Metabolic dysfunction-associated fatty liver disease (MAFLD)/nonalcoholic fatty liver disease (NAFLD) has gradually risen to the top of chronic liver disease worldwide. The mechanism leading to the occurrence and development of this disease has been the focus of many scholars and clinicians. Macrophages， as one of the important cells involved in the pathogenesis of MAFLD， play an essential role in the pathogenesis and disease progression of MAFLD. In this paper， the source and classification of liver macrophages， the correlation between macrophages and MAFLD disease spectrum， and the correlation between macrophages and the pathogenesis of MAFLD such as inflammation， immune response， insulin resistance(IR) ......