陶玉龙 冯文明 黄三雄

    [摘要] 目的 探讨预防性肝动脉灌注化疗(HAIC)对胰腺癌(PC)术后长期生存的影响。 方法 收集2010年6月至2015年5月间在湖州师范学院附属第一医院接受手术切除的87例PC患者资料。根据术后辅助化疗模式，将患者分为HAIC组(n=43)和对照组(n=44)。HAIC组术后接受2个周期HAIC和4个周期静脉化疗，对照组接受6个疗程静脉化疗。观察两组长期生存情况及化疗毒性。 结果 HAIC组5年总生存率为25.58%，对照组为18.18%，HAIC组显著高于对照组(P<0.05)。两组的毒副作用比较，差异无统计学意义(P>0.05)，无化疗相关死亡发生。 结论 预防性肝动脉灌注化疗可显著改善胰腺癌术后患者长期生存，且安全性好。

    [关键词] 胰腺癌;肝动脉灌注化疗;静脉化疗;长期生存

    [中图分类号] R735.9? ? ? ? ? [文献标识码] B? ? ? ? ? [文章编号] 1673-9701(2022)02-0053-04

    Effect of preventive hepatic arterial infusion chemotherapy on long-term survival after pancreatic cancer surgery

    TAO Yulong? ?FENG Wenming? ?HUANG Sanxiong

    Department of Surgery， the First Affiliated Hospital of Huzhou Teachers College， Huzhou? ?313000， China

    [Abstract] Objective To investigate the effect of preventive hepatic arterial infusion chemotherapy (HAIC) on long-term survival after pancreatic cancer (PC) surgery. Methods The data of 87 PC patients who underwent surgical resection in the First Affiliated Hospital of Huzhou Teachers College from June 2010 to May 2015 were collected. They were divided into the HAIC group (43 patients) and the control group (44 patients) ......