荣清青 徐鹏

    [摘要] 卵圆孔是房间隔中部的裂隙，出生后多数人可自然关闭，卵圆孔未闭(patent foramen ovale，PFO)是指3岁以上的人卵圆孔仍未关闭。偏头痛(migraine)在临床上是一种常见的大脑神经和血管功能紊乱的疾病，在神经系统疾病发病率中位居第二位。PFO在偏头痛患者中的发病率很高，但二者之间的关系仍未确定，但PFO封堵后部分患者偏头痛症状得以缓解。本文对PFO引起偏头痛的机制、PFO封堵术及右向左残余分流对偏头痛影响的相关研究进展进行综述。

    [关键词] 卵圆孔未闭;偏头痛;封堵术;右向左残余分流

    [中图分类号] R741? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2022)11-0193-04

    [Abstract] The foramen ovale is a fissure in the middle of the atrial septum， which can be closed naturally by most people after birth. And patent foramen ovale (PFO) is called PFO if the foramen ovale is still not closed after 3 years old. Migraine is a common chronic neurovascular disease， which ranks second in the incidence of nervous system diseases.PFO is more common in patients with migraine，and the relationship mechanism between migraine and PFO is not clear.However，after PFO occlusion， migraine symptoms were alleviated in some patients.The mechanism of migraine caused by PFO， the related research progress of PFO occlusion and the impact of right-left residual shunt on migraine was reviewed in this article.

    [Key words] Patent foramen ovale; Migraine; Occlusion; Right-left residual shunt ......