郭素燕 谭健华

    [摘要] 目的 研究分析TCT检测筛查不能明确意义的非典型鳞状细胞(ASCUS)发生HSIL的高危因素。方法 回顾性分析2017年1月至2021年4月于广东省汕头市第三人民医院妇产科经TCT检测筛查提示为ASCUS患者118例的临床资料，分析ASCUS发生HSIL的高危因素。 结果 118例TCT诊断为ASCUS患者经活检病理金标准，其中炎症改变27.97%(33/118)、LSIL56.78%(67/118)、HSIL15.25%(18/118)，HR-HPV检测HSIL的敏感度为88.89%(16/18)，阴性预测值为97.18%(69/71);研究组与对照组在首次性生活年齡、流产次数、HR-HPV及绝经比较，差异有统计学意义(P<0.05);经logistics回归分析显示，首次性生活年龄≤20岁、流产次数≥2次、HR-HPV阳性及绝经为HSIL发生的高危因素。结论 首次性生活年龄≤20岁、流产次数≥2次、HR-HPV阳性及绝经为HSIL发生的高危因素，临床应及早干预。

    [关键词] TCT;ASCUS;HSIL;高危因素

    [中图分类号] R711.74? ? ? ? ? [文献标识码] B? ? ? ? ? [文章编号] 1673-9701(2022)12-0057-03

    [Abstract] Objective To analyze the high risk factors of HSIL in atypical squamous cells (ASCUS) which cannot be clearly screened by TCT. Methods The clinical data of 118 ASCUS patients screened by TCT in the Department of Obstetrics and Gynecology in the Third People′s Hospital of Shantou City in Guangdong Province from January 2017 to April 2021 were analyzed retrospectively. The high risk factors of HSIL in ASCUS were analyzed. Results Among 118 patients diagnosed as ASCUS by TCT ......