胡彩虹 饶先林 吴红娣 陆增生

    [摘要] 目的 探讨感染科患者发生抗生素相关性腹泻(AAD)的发病机制及其危险因素，为临床早期预防提供依据。方法 选取2018年6月至2020年10月浙江省立同德医院感染科收治的283例患者进行随访调查，依据其住院期间是否发生AAD将其分为AAD组(77例)和非AAD组(206例);分析感染科患者住院期间的AAD发生率，比较两组患者间的各因素分布差异性，并采用逐步logistic回归法筛选影响感染科患者发生AAD的相关危险因素。结果 283例感染科患者住院期间AAD发生率为27.21%(77/283);影响感染科患者住院期间发生AAD的危险因素包括年龄(OR=3.117)、营养风险(OR=4.035)、病情危重(OR=4.586)、联用抗生素(OR=4.175)、抗生素使用时间(OR=2.807)、住院时间(OR=2.246)，而使用微生态制剂(OR=0.483)则为保护性因素。结论 感染科患者住院期间的AAD发生率高达27.21%，应摸清AAD的发病机制及其相关高危因素，早期采取预防措施，降低感染科的AAD发生率，改善患者的预后。

    [关键词] 感染科;抗生素相关性腹泻;菌群失调;危险因素

    [中图分类号] R969.3? ? ? ? ? [文献标识码] B? ? ? ? ? [文章编号] 1673-9701(2022)13-0000-04

    [Abstract] Objective To explore the pathogenesis and risk factors of antibiotic-associated diarrhea (AAD) in patients with infectious diseases， and to provide evidence for early clinical prevention. Methods A follow-up survey was conducted on 283 patients admitted to the Department of Infectious Disease of Tongde Hospital of Zhejiang Province from June 2018 to October 2020. They were divided into the AAD group (77 patients) and the non-AAD group (206 patients) according to whether AAD occurred during hospitalization. The incidence of AAD during hospitalization was analyzed. The differences in the distribution of various factors were compared between the two groups. The stepwise logistic regression method was used to screen the relevant risk factors of AAD in infectious diseases. Results The incidence of AAD during hospitalization of 283 patients in the Department of Infectious Disease was 27.21% (77/283). The risk factors of AAD during hospitalization in patients in the Department of Infectious Disease included age (OR=3.117) ......