田萍萍 陈燕媚

    [摘要] 目的 探討早期糖尿病肾病患者进行多项生化检测指标诊断的准确性及应用价值。 方法 选择2020年1～12月期间厦门市海沧医院收诊治疗的糖尿病肾病患者80例为观察组，选择同期于厦门市海沧医院进行体检的健康者80例为对照组，均接受多项生化指标检测，包括尿白蛋白/尿肌酐(urine albumin/urine creatinine，UALB/UCr)、α₁-微球蛋白(α₁-microglobulin，α₁-MG)、视黄醇结合蛋白(retinol binding protein，RBP)、血清胱抑素(serum cystatin，Cys C)、超敏C-反应蛋白(high-sensitivity c-reactive protein， hs-CRP)、同型半胱氨酸(homocysteine，Hcy)，比较检测结果差异性，统计不同生化检测指标检出糖尿病肾病阳性率。 结果 观察组尿白蛋白/血肌酐(42.63±5.58)mg/gCr、血清胱抑素(1.18±0.03)mg/L等多项生化检测结果均明显高于对照组(P1-microglobulin (α₁-MG)， retinol binding protein (RBP)，serum cystatin(Cys C)，high-sensitivity C-reactive protein (hs-CRP) and homocysteine(Hcy).The difference between the two groups was recorded and the positive rate of diabetic nephropathy detected by different biochemical detection indicators was counted. Results The multiple biochemical detection results including urine albumin/urine creatinine [(42.63±5.58)mg/gCr] and serum cystatin [(1.18±0.03)mg/L]for patients with diabetic nephropathy in the observation group were significantly higher than those in the control group(P0.05) ......