孙景熙 陈剑明 王福斌 毛振宇

    1. 寧波市第六医院，浙江宁波 315040;2.宁波大学附属人民医院，浙江宁波 315040

    [摘要] 目的 探讨骨代谢标志物检测在乳腺癌中的诊断价值，为临床推广应用提供实验依据。方法? 回顾性分析选取2015年1月～2020年1月宁波大学附属人民医院收治的100例乳腺癌患者为本次研究的研究对象，分为研究组(骨转移组，n=50)和对照组(非骨转移组，n=50)，查找其治疗期间的病历资料，检测Ⅰ型前胶原N-端前肽(PINP)和Ⅰ型胶原羧基端肽β特殊序列(β-CTX)表达水平。结果? 研究组骨代谢标志物明显高于对照组，差异有统计学意义(P<0.01)，PINP检测诊断乳腺癌骨转移的特异性和敏感度分别为77.4%、80.9%，β-CTX骨转移分别为68.5%、71.7%;PINP及β-CTX联合检测诊断乳腺癌骨转移的特异性和敏感度分别为81.9%、86.4%。结论? 血清学PINP和β-CTX水平与乳腺癌骨转移有相关性，血清PINP和β-CTX可作为乳腺癌骨转移的辅助血清学诊断指标，值得推广。

    [关键词] 骨代谢标志物;乳腺癌;骨转移;诊断价值

    [中图分类号] R737.9? ? ? &nbsp; ? [文献标识码] A? ? ? ? ? [文章编号] 1673-9701(2022)17-0024-03

    Significance of serum PINP and β-CTX in the diagnosis of breast cancer bone metastasis

    SUN Jingxi1? ?CHEN Jianming1? WANG Fubin1? MAO Zhenyu2

    1.Ningbo No.6 Hospital， Ningbo? 315042， China; 2.the Affiliated People's Hospital of Ningbo University， Ningbo? 315040， China

    [Abstract] Objective To investigate the diagnostic value of procollagen type I N-terminal propeptide (PINP) and specific sequence β carboxy-terminal cross-linking telopeptide of type I collagen (β-CTX) detection in breast cancer. Methods A total of 100 patients with breast cancer diagnosed and treated in the Affiliated People's Hospital of Ningbo University from January 2015 to January 2020 were retrospectively analyzed and divided into the study group (bone metastasis group ......