沈春娟 许胜峰 许正芬

    [摘要] 目的 探究治疗前1小时经阴道给予患者米索前列醇400?g，对高强度聚焦超声(high intensity focused ultrasound，HIFU)治疗子宫肌瘤的超声时间及治疗效果的影响。方法 回顾性分析2020年7月至2022年1月在嘉兴市妇幼保健院诊断为子宫肌瘤并接受HIFU治疗的患者123例，按照治疗方法分为常规HIFU治疗组(对照组，n=66)和米索前列醇联合HIFU治疗组(米索前列醇组，n=57)，比较两组的超声时间，治疗中、治疗后不良并发症，治疗后6个月子宫肌瘤体积及临床症状随访。结果 米索前列醇组术中出现治疗区疼痛率显著高于对照组，差异有统计学意义(P0.05)。结论 在HIFU治疗前1小时对患者经阴道给予400?g米索前列醇治疗子宫肌瘤，可显著缩短超声时间，对提高治疗效率有着积极作用，但并未显著减小治疗后6月的子宫肌瘤体积及减轻患者相关临床症状。

    [关键词] 高强度聚焦超声；子宫肌瘤；米索前列醇；超声时间

    [中图分类号] R737；R454? ? ? [文献标识码] A? ? ? [DOI] 10.3969/j.issn.1673-9701.2023.02.023

    [Abstract] Objective To investigate the effect of misoprostol 400?g given vaginally 1 hour before treatment on the duration of ultrasound and treatment outcome of uterine fibroids treated with high intensity focused ultrasound (HIFU). Methods A total of 123 patients diagnosed with uterine fibroids and treated with HIFU at Jiaxing Maternity and Child Health Care Hospital from July 2020 to January 2022 were retrospectively analyzed and divided into conventional HIFU treatment group (the control group ......