王岩 叶志坚

    [摘要] 目的 探讨不同剂量盐酸羟考酮对腹腔镜子宫切除术患者的应用效果。方法 回顧性收集2019年5月至2021年12月于金华市人民医院行腹腔镜子宫切除术的62例患者的病历资料，根据患者术后镇痛使用的盐酸羟考酮剂量分为Ⅰ组(n=30)和Ⅱ组(n=32)，Ⅰ组剂量为0.1mg/kg，Ⅱ组剂量为0.15mg/kg。比较两组术后疼痛应激反应、氧化应激反应、炎症、不良反应发生情况。结果 Ⅱ组术后4h、8h、12h以及24h时视觉模拟评分(visual analogue scale，VAS)均低于Ⅰ组，差异有统计学意义(P0.05)。结论 相较于0.1mg/kg剂量，0.15mg/kg剂量的盐酸羟考酮更有利于缓解腹腔镜子宫切除术患者术后疼痛程度，减轻术后应激反应和炎症，且不增加药物不良反应发生风险。

    [关键词] 盐酸羟考酮；腹腔镜子宫切除术；疼痛应激；炎症

    [中图分类号] R713.4? ? ? [文献标识码] A? ? ? [DOI] 10.3969/j.issn.1673-9701.2023.02.026

    [Abstract] Objective To investigate the effccts of different doses of oxycodone hydrochloride on laparoscopic hysterectomy. Methods The medical records of 62 patients who underwent laparoscopic hysterectomy in Jinhua Municipal People's Hospital from May 2019 to December 2021 were retrospectively collected and divided into group Ⅰ (n=30) and group Ⅱ (n=32) according to the dose of oxycodone hydrochloride used after operation. The doses of oxycodone hydrochloride in group Ⅰ and group Ⅱ were 0.1mg/kg and 0.15mg/kg. Postoperative pain stress response ......